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Ischemia-induced irreversible deficit of memory function in gerbils
- A. Katoh, C. Ishibashi, T. Shiomi, Y. Takahara, M. Eigyo
- Medicine, Biology
- Brain Research
- 10 April 1992
5-min ischemia led to a reversible memory deficit, while 20-min and repeated ischemian produced an irreversible deficit, which indicated that gerbils trained for an 8-arm radial maze task had an irreversible deficits. Expand
Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats.
- A. Katoh, M. Eigyo, +5 authors A. Matsushita
- The Journal of pharmacology and experimental…
- 1 March 1995
The results indicated that duloxetine produced behavioral and electroencephalographic responses resulting from the inhibition of norepinephrine and serotonin reuptake in vivo, and that it had a weak anticholinergic action, which may be clinically useful as an antidepressant. Expand
Central action of atrial natriuretic polypeptide on blood pressure in conscious rats
The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats, and data implicate atrialNatriUREtic polyPEptide as a factor in blood pressure regulation in the central nervous system. Expand
Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats
Results suggest that ANP in the brain is involved in the regulation of the hypothalamo-pituitary-adrenal axis and attenuated the plasma corticosterone increase induced by centrally injected AII dose-dependently. Expand
[Pharmacological studies of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivatives (450191-S) (I). Behavioral analysis].
- K. Yamamoto, K. Hirose, +7 authors Y. Tsukinoki
- Nihon yakurigaku zasshi. Folia pharmacologica…
- 1 July 1984
Results indicate that 450191-S possesses inhibitory effects on the central nervous system, including a potent sleep-inducing effect, and is characterized by markedly weak muscle relaxant activity and motor incoordination. Expand
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent.
- H. Shindo, S. Takada, S. Murata, M. Eigyo, A. Matsushita
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 June 1989
Introduction of alkyl groups of different sizes into the unsubstituted inverse agonistic compounds results in a corresponding shift in the activity from an inverse agonist to an antagonist to an agonist. Expand
Protective effect of CCK-8 and ceruletide on glutamate-induced neuronal cell death in rat neuron cultures: Possible involvement of CCK-B receptors
- G. Katsuura, S. Shinohara, H. Shintaku, M. Eigyo, A. Matsushita
- Biology, Medicine
- Neuroscience Letters
- 11 November 1991
Findings clearly indicate that CCK-8, CLT and gastrin-I exhibit a protective effect against glutamate-induced neurotoxicity via theCCK-B receptor. Expand
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole or bemegride, no effects were observed in convulsion induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice. Expand
A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer
- K. Kawasaki, M. Eigyo, +7 authors M. Yasui
- Psychology, Medicine
- Progress in Neuro-Psychopharmacology and…
- 1 November 1996
It is suggested that S-8510 can be used as a therapeutic drug for senile dementia, including Alzheimer's disease with little risk for inducing anxiety or convulsion. Expand
A new thienylpyrazoloquinoline: a potent and orally active inverse agonist to benzodiazepine receptors.