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Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
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Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.
TLDR
Heparan sulfate, which is present on the endothelial cell surface and in the basement membrane, may have a dual function in diapedesis, promotion of IL-8-dependent transmigration of neutrophils, and protection of the tissue microenvironment from damage by lytic enzymes released from the migrating cells.
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Novel Semliki Forest virus vectors with reduced cytotoxicity and temperature sensitivity for long-term enhancement of transgene expression.
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The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes.
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Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain
TLDR
It is shown that Homer1a operates in a negative feedback loop to regulate the excitability of the pain pathway in an activity-dependent manner and constitutes a promising therapeutic target for the treatment of chronic inflammatory pain.
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Gene Transfer into Neurons from Hippocampal Slices: Comparison of Recombinant Semliki Forest Virus, Adenovirus, Adeno-Associated Virus, Lentivirus, and Measles Virus
TLDR
SFV is useful for short-term and AAV and lentivirus for long-term transduction of hippocampal slices, while MV constitutes a novel vector for transferring genes into neurons.
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Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst
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K+-dependent Cerebellar Granule Neuron Apoptosis
TLDR
TASK leak K+ channels play an important role in K+-dependent apoptosis of cerebellar granule neurons in culture and are prevented by conditions that specifically reduce K+ efflux through the TASK-3 channels such as extracellular acidosis and ruthenium red.
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EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis*
TLDR
Coupling adenoviral overexpression with microarray and quantitative reverse transcription-polymerase chain reaction analyses could be a versatile strategy for identifying target genes of transactivators.
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Quantitative real-time PCR for the measurement of feline cytokine mRNA
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