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Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.
- L. Webb, M. Ehrengruber, I. Clark‐Lewis, M. Baggiolini, A. Rot
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 August 1993
Heparan sulfate, which is present on the endothelial cell surface and in the basement membrane, may have a dual function in diapedesis, promotion of IL-8-dependent transmigration of neutrophils, and protection of the tissue microenvironment from damage by lytic enzymes released from the migrating cells.
Novel Semliki Forest virus vectors with reduced cytotoxicity and temperature sensitivity for long-term enhancement of transgene expression.
The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes.
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain
It is shown that Homer1a operates in a negative feedback loop to regulate the excitability of the pain pathway in an activity-dependent manner and constitutes a promising therapeutic target for the treatment of chronic inflammatory pain.
Gene Transfer into Neurons from Hippocampal Slices: Comparison of Recombinant Semliki Forest Virus, Adenovirus, Adeno-Associated Virus, Lentivirus, and Measles Virus
- M. Ehrengruber, S. Hennou, H. Büeler, H. Naim, N. Déglon, K. Lundstrom
- BiologyMolecular and Cellular Neuroscience
- 1 May 2001
SFV is useful for short-term and AAV and lentivirus for long-term transduction of hippocampal slices, while MV constitutes a novel vector for transferring genes into neurons.
Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst
K+-dependent Cerebellar Granule Neuron Apoptosis
TASK leak K+ channels play an important role in K+-dependent apoptosis of cerebellar granule neurons in culture and are prevented by conditions that specifically reduce K+ efflux through the TASK-3 channels such as extracellular acidosis and ruthenium red.
EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis*
- J. Svaren, T. Ehrig, S. Abdulkadir, M. Ehrengruber, M. Watson, J. Milbrandt
- BiologyThe Journal of Biological Chemistry
- 8 December 2000
Coupling adenoviral overexpression with microarray and quantitative reverse transcription-polymerase chain reaction analyses could be a versatile strategy for identifying target genes of transactivators.