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Genome sequencing in microfabricated high-density picolitre reactors
TLDR
A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described. Expand
A core gut microbiome in obese and lean twins
TLDR
The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome. Expand
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. Expand
The genome of the domesticated apple (Malus × domestica Borkh.)
TLDR
It is shown that a relatively recent (>50 million years ago) genome-wide duplication has resulted in the transition from nine ancestral chromosomes to 17 chromosomes in the Pyreae, which partly support the monophyly of the ancestral paleohexaploidy of eudicots. Expand
Comprehensive human genome amplification using multiple displacement amplification
TLDR
MDA-based whole genome amplification by multiple displacement amplification is a simple and reliable method that could have significant implications for genetic studies, forensics, diagnostics, and long-term sample storage. Expand
A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder
TLDR
The observation that irradiated combs from affected colonies can be repopulated with naive bees suggests that infection may contribute to colony collapse disorder (CCD). Expand
The complete genome of an individual by massively parallel DNA sequencing
TLDR
This sequence was completed in two months at approximately one-hundredth of the cost of traditional capillary electrophoresis methods and demonstrated the acquisition of novel human sequence, including novel genes not previously identified by traditional genomic sequencing, which is the first genome sequenced by next-generation technologies. Expand
The tomato genome sequence provides insights into fleshy fruit evolution
TLDR
A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome. Expand
Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome
TLDR
High-throughput and massive paired-end mapping (PEM) was used to map SVs in an African and in a putatively European individual and identified shared and divergent SVs relative to the reference genome, documenting that the number of SVs among humans is much larger than initially hypothesized; many of the SVs potentially affect gene function. Expand
Analysis of one million base pairs of Neanderthal DNA
TLDR
A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Expand
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