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Genome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencingExpand
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A core gut microbiome in obese and lean twins
The human distal gut harbours a vast ensemble of microbes (the microbiota) that provide important metabolic capabilities, including the ability to extract energy from otherwise indigestible dietaryExpand
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A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder
In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. TheExpand
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The complete genome of an individual by massively parallel DNA sequencing
The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. However, theExpand
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Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome
Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of rearrangements. We introduce high-throughput andExpand
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Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing
BackgroundWhole genome amplification is an increasingly common technique through which minute amounts of DNA can be multiplied to generate quantities suitable for genetic testing and analysis.Expand
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Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins
We deeply sampled the organismal, genetic, and transcriptional diversity in fecal samples collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communities from the gut andExpand
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Wasp Gene Expression Supports an Evolutionary Link Between Maternal Behavior and Eusociality
The presence of workers that forgo reproduction and care for their siblings is a defining feature of eusociality and a major challenge for evolutionary theory. It has been proposed that workerExpand
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Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA
Whereas evolutionary inferences derived from present-day DNA sequences are by necessity indirect, ancient DNA sequences provide a direct view of past genetic variants. However, base lesions thatExpand
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Mixed-Layer Deepening During Heinrich Events : A Multi-Planktonic Foraminiferal d 18 O Approach
Proxies from Greenland ice cores and North Atlantic marine sediment cores document repeated extreme climate swings of a few decades to millennia during the last glacial cycle, including periods ofExpand
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