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The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus
Balanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show thatExpand
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MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
  • L. Chan, T. Webb, +9 authors A. Clark
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 April 2009
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic–pituitary–adrenal axis,Expand
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Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C‐terminal tail of CB1
The CB1‐type cannabinoid receptor mediates physiologic effects of Δ9‐tetrahydrocannabinol, the psychoactive ingredient of the drug marijuana. In this report, the authors analyse the expression of CB1Expand
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The neurobiology and evolution of cannabinoid signalling.
The plant Cannabis sativa has been used by humans for thousands of years because of its psychoactivity. The major psychoactive ingredient of cannabis is Delta(9)-tetrahydrocannabinol, which exertsExpand
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Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of
Fatty acid amide hydrolase (FAAH) catalyses hydrolysis of the endocannabinoid arachidonoylethanolamide ("anandamide") in vitro and regulates anandamide levels in the brain. In the cerebellar cortex,Expand
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Cannabinoid CB1 Receptor Expression in Rat Spinal Cord
While evidence implicates the endogenous cannabinoid system as a novel analgesic target at a spinal level, detailed analysis of the distribution of the cannabinoid receptor CB1 in spinal cord has notExpand
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A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
CB1–type cannabinoid receptors in the brain mediate effects of the drug cannabis. Anandamide and sn–2 arachidonylglycerol (2–AG) are putative endogenous ligands for CB1 receptors, but it is not knownExpand
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CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a
The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection. We report the discovery of twoExpand
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Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry
In this study we used in situ hybridisation and double-labelling immunohistochemistry to characterise cannabinoid receptor 1 (CB(1)) expression in rat lumbar dorsal root ganglion (DRG)Expand
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Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules
N‐acylethanolamines (NAEs) are membrane‐derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide). An N‐acyl phosphatidylethanolamineExpand
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