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The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
TLDR
A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF. Expand
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
TLDR
The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia. Expand
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
TLDR
Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for processing of negative emotion, particularly perigenual cingulate and amygdala, and relative uncoupling of this circuit. Expand
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.
TLDR
Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function. Expand
Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
TLDR
Genetically driven variation in the response of brain regions underlying human emotional behavior is demonstrated and differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele. Expand
Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.
TLDR
Patients with schizophrenia whose performance on the N-back working memory task is similar to that of healthy comparison subjects use greater prefrontal resources but achieve lower accuracy and that other patients with schizophrenia fail to sustain the prefrontal network that processes the information, achieving even lower accuracy as a result. Expand
Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
TLDR
The relationship of the BDNF val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals suggests that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans. Expand
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
TLDR
Basic evidence of an inverted-“U” functional-response curve to increasing dopamine signaling in the prefrontal cortex is extended and individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine. Expand
The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
TLDR
It is shown that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory. Expand
Neural mechanisms of genetic risk for impulsivity and violence in humans.
TLDR
The data identify differences in limbic circuitry for emotion regulation and cognitive control that may be involved in the association of MAOA with impulsive aggression, suggest neural systems-level effects of X-inactivation in human brain, and point toward potential targets for a biological approach toward violence. Expand
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