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Review: Hyperthermia and fever during pregnancy.
  • M. Edwards
  • Medicine
    Birth defects research. Part A, Clinical and…
  • 1 July 2006
TLDR
Suggested future human studies include problems of CNS function after exposure to influenza and fever, including mental retardation, schizophrenia, autism, and cerebral palsy.
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Effects of heat on embryos and foetuses
TLDR
In humans, epidemiological studies suggest that an elevation of maternal body temperature by 2°C for at least 24 h during fever can cause a range of developmental defects, but there is little information on thresholds for shorter exposures.
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Hyperthermia as a teratogen: parameters determining hyperthermia-induced head defects in the rat.
TLDR
Microphthalmia was the most common malformation at all teratogenic temperatures and was frequently the only malformation seen at the shortest time exposure for a particular temperature.
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Apoptosis, the heat shock response, hyperthermia, birth defects, disease and cancer. Where are the common links?
  • M. Edwards
  • Biology
    Cell stress & chaperones
  • 1 December 1998
TLDR
The heat shock (HS) response occurs in a wide range of plants and animals as a basic reaction that assists survival and recovery from the effects of heat and other toxic agents.
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Heat shock and thermotolerance during early rat embryo development.
TLDR
The results illustrate the sensitivity of the developing head and brain to elevated temperatures prior to neural tube closure and the capacity of embryos to acquire thermotolerance.
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Hyperthermic teratogenicity, thermal dose and diagnostic ultrasound during pregnancy: implications of new standards on tissue heating
TLDR
informed use of and attention to the TI is strongly advised, with this admonition gaining increased emphasis if the present regulations regarding allowable acoustic outputs of DUS devices were to be further relaxed or eliminated.
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Hyperthermia as a teratogen: a review of experimental studies and their clinical significance.
  • M. Edwards
  • Medicine, Biology
    Teratogenesis, carcinogenesis, and mutagenesis
  • 1986
TLDR
Hyperthermia appears to be capable of causing congenital defects in all species and may act alone or synergistically with other agents.
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Mitotic cell death and delay of mitotic activity in guinea-pig embryos following brief maternal hyperthermia.
TLDR
Pregnant guinea-pigs exposed to an environmental temperature of 42·0–42·5 °C for 1 h on day 21 of gestation and their embryos were removed at periods from 45 min of heating to 48 h following exposure, indicating blocks to the cell generation cycle before prophase and in metaphase.
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Hyperthermia and birth defects.
  • M. Edwards
  • Medicine
    The Cornell veterinarian
  • 1 September 1995
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Congenital malformations in the rat following induced hyperthermia during gestation.
TLDR
Hyperthermia induced in pregnant rats by exposures for 40 to 60 minutes in an incubator that raised deep body temperatures produced increased fetal resorptions, retardation of growth, and a number of development defects.
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