• Publications
  • Influence
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results inExpand
  • 1,606
  • 101
The UVic earth system climate model: Model description, climatology, and applications to past, present and future climates
Abstract A new earth system climate model of intermediate complexity has been developed and its climatology compared to observations. The UVic Earth System Climate Model consists of aExpand
  • 612
  • 60
  • PDF
Atmospheric lifetime of fossil-fuel carbon dioxide
CO2 released from combustion of fossil fuels equilibrates among the various carbon reservoirs of the atmosphere, the ocean, and the terrestrial biosphere on timescales of a few centuries. However, aExpand
  • 533
  • 37
  • PDF
A Deubiquitinase That Regulates Type I Interferon Production
Production of type I interferon (IFN-I) is a critical host defense triggered by pattern-recognition receptors (PRRs) of the innate immune system. Deubiquitinating enzyme A (DUBA), an ovarian tumorExpand
  • 396
  • 23
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
The NF-kappaB family of transcription factors is activated in response to many stimuli, including pro-inflammatory cytokines, environmental stresses and, in the case of B and T lymphocytes, byExpand
  • 204
  • 23
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
The NF-κB family of transcription factors is activated in response to many stimuli, including pro-inflammatory cytokines, environmental stresses and, in the case of B and T lymphocytes, by antigenicExpand
  • 489
  • 21
Simulated influence of carbon dioxide, orbital forcing and ice sheets on the climate of the Last Glacial Maximum
A coupled atmosphere–ocean–sea-ice model is used to investigate the climate of the Last Glacial Maximum (∼21,000 years ago) and the relative climate-forcing effects of atmosphere CO2, the Earth'sExpand
  • 230
  • 17
  • PDF
IPCC Fifth Assessment Synthesis Report-Climate Change 2014 Synthesis Report
  • 161
  • 15
ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
The ataxia telangiectasia mutated (ATM) protein kinase is a critical component of a DNA-damage response network configured to maintain genomic integrity. The abundance of an essential downstreamExpand
  • 137
  • 11
Nonlinearity of Carbon Cycle Feedbacks
AbstractCoupled climate–carbon models have shown the potential for large feedbacks between climate change, atmospheric CO2 concentrations, and global carbon sinks. Standard metrics of this feedbackExpand
  • 46
  • 11
  • PDF