Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
- I. Wertz, K. O'Rourke, +10 authors V. Dixit
- Biology, Medicine
- Nature
- 5 August 2004
NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results in… Expand
The UVic earth system climate model: Model description, climatology, and applications to past, present and future climates
- A. Weaver, M. Eby, +12 authors Masakazu Yoshimori
- Environmental Science
- 1 December 2001
Abstract A new earth system climate model of intermediate complexity has been developed and its climatology compared to observations. The UVic Earth System Climate Model consists of a… Expand
Atmospheric lifetime of fossil-fuel carbon dioxide
CO2 released from combustion of fossil fuels equilibrates among the various carbon reservoirs of the atmosphere, the ocean, and the terrestrial biosphere on timescales of a few centuries. However, a… Expand
A Deubiquitinase That Regulates Type I Interferon Production
- N. Kayagaki, Q. Phung, +10 authors V. Dixit
- Biology, Medicine
- Science
- 7 December 2007
Production of type I interferon (IFN-I) is a critical host defense triggered by pattern-recognition receptors (PRRs) of the innate immune system. Deubiquitinating enzyme A (DUBA), an ovarian tumor… Expand
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
- Honglin Zhou, I. Wertz, +5 authors V. Dixit
- Medicine
- Nature
- 2004
The NF-kappaB family of transcription factors is activated in response to many stimuli, including pro-inflammatory cytokines, environmental stresses and, in the case of B and T lymphocytes, by… Expand
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
- Honglin Zhou, I. Wertz, +5 authors V. Dixit
- Biology
- Nature
- 8 January 2004
The NF-κB family of transcription factors is activated in response to many stimuli, including pro-inflammatory cytokines, environmental stresses and, in the case of B and T lymphocytes, by antigenic… Expand
Simulated influence of carbon dioxide, orbital forcing and ice sheets on the climate of the Last Glacial Maximum
- A. Weaver, M. Eby, A. Fanning, Edward C. Wiebe
- Geology
- Nature
- 27 August 1998
A coupled atmosphere–ocean–sea-ice model is used to investigate the climate of the Last Glacial Maximum (∼21,000 years ago) and the relative climate-forcing effects of atmosphere CO2, the Earth's… Expand
ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
- D. Dornan, Harumi Shimizu, +5 authors V. Dixit
- Biology, Medicine
- Science
- 25 August 2006
The ataxia telangiectasia mutated (ATM) protein kinase is a critical component of a DNA-damage response network configured to maintain genomic integrity. The abundance of an essential downstream… Expand
Nonlinearity of Carbon Cycle Feedbacks
- K. Zickfeld, M. Eby, H. Matthews, A. Schmittner, A. Weaver
- Environmental Science
- 1 December 2010
AbstractCoupled climate–carbon models have shown the potential for large feedbacks between climate change, atmospheric CO2 concentrations, and global carbon sinks. Standard metrics of this feedback… Expand