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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan. Expand
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra. Expand
Aggression, suicide, and serotonin: relationships to CSF amine metabolites.
The life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder were examined, and Histories of aggressive behaviors and of suicide attempts were significantly associated with each other. Expand
Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins.
A new silver stain for electrophoretically separated polypeptides can be rapidly and easily used and can detect as little as 0.01 nanogram of protein per square millimeter. When employed withExpand
Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients.
In underweight anorexics, the pituitary responds appropriately to corticotropin-releasing hormone, being restrained in its response by the elevated levels of cortisol, which suggests that hypercortisolism in anorexia nervosa reflects a defect at or above the hypothalamus. Expand
Labile methyl group balances in the human: the role of sarcosine.
New data on methionine consumption due to sarcosine formation permit calculation of a turnover time for S-adenosylmethionine in human liver (no more than 3.5–7 min), as well as upward revision of previous minimal estimates of the rate of methylneogenesis, the number of times that the average homocysteinyl moiety cycles between methionsine and homocysteine during its passage through the body. Expand
A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa.
It is suggested that Δ9-THC is not efficacious, in short-term administration, in the treatment of primary anorexia nervosa and is associated with significant psychic disturbance in some PAN patients. Expand
Huntington's dementia. Clinical and neuropsychological features.
The neuropsychiatric syndrome of Huntington's disease is outlined in this report with an emphasis on the cognitive deficits that lend themselves to future neurobehavioral research. Eighteen patientsExpand
Abnormalities in CNS monoamine metabolism in anorexia nervosa.
Underweight anorectics have state-associated disturbances in dopamine and serotonin metabolism and abnormalities in neurotransmitter metabolism are part of the neurobiological syndrome of anorexia nervosa and may contribute to the characteristic changes in mood, behavior, and neuroendocrine function. Expand