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Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N-Nitroso Compounds
The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments)Expand
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Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.
Six nitrosamides [ethylnitrosourea (ENU), 2-hydroxyethylnitrosourea (HENU), carboxymethylnitrosourea, 1-nitroso-5,6-dihydrouracil (NDHU), 1-nitrosohydantoin, and N-methyl-N-nitrosobenzamide (MNB)]Expand
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Carcinogenic effect of 2,2'-dimethyldipropylnitrosamine in Syrian hamsters.
Oxidation at the beta carbon occurred in metabolism of di-n-propylnitrosamine (DPN), previously shown to be carcinogenic for animals. When 2,2'-dimethyldipropylnitrosamine (DMDPN) was injected scExpand
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Kinetics of the nitrosation of aminopyrine to give dimethylnitrosamine
The initial rate of nitrosation of aminopyrine (AP, Pyramidon) to give dimethyl nitrosamine (DMN) showed maxima at pH 2.0 and 3.1. At pH 2, initial rate was proportional to nitrite concentrationExpand
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Transplacental effects of nitrosamines in Syrian hamsters: I. Dibutylnitrosamine and nitrosohexamethyleneimine
The transplacental carcinogenic effects of dibutylnitrosamine (DBN) and nitrosohexamethyleneimine (N-6-MI) were examined in Syrian hamsters. A proportion of both substances reached the fetal tissueExpand
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