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Rapid preparation and quality control method for technetium-99m-2-methoxy isobutyl isonitrile (technetium-99m-sestamibi).
TLDR
The combined use of the microwave oven heating method and the quick quality control system will facilitate the rapid, emergency use of 99mTc-sestamibi and eliminate the need for advance preparation of multiple kits each day.
Comparison of four alternative radiochemical purity testing methods for 99Tcm-sestamibi.
Four different methods for determining the radiochemical purity (RCP) of 99Tcm-sestamibi have been proposed to replace the recommended thin-layer chromatography (TLC) method, as the recommended
Radiochemical purity testing for 99Tcm-exametazime: a comparison study for three‐paper chromatography
TLDR
This study was undertaken to compare the standard TP method with two other proposed single-strip chromatography systems: Whatman 17 Chr paper with ethyl acetate (THE AUTHORS) and Gelman Solvent Saturation Pads paper with ether (GE), and found that the GE method has the most clear separation of lipophilic 99Tcm-exametazime from other radiochemical impurities and offers the quickest RCP analysis with relatively accurate results.
Generator eluate effects on the labeling efficiency of 99mTc-sestamibi.
TLDR
The use of a first elution from a long-ingrowth time generator at a later stage in preparation of a 99mTc-sestamibi kit is associated with a high rate of kit failure and should therefore be avoided.
An alternative method for rapid preparation of 99Tcm-sestamibi.
TLDR
The use of an instant hot water machine not only avoids those problems associated with the microwave heating method, but also provides a rapid, efficient and relatively simple option for preparation of 99Tcm-sestamibi.
Microwave preparation of and one-strip paper chromatography for technetium Tc 99m teboroxime.
  • M. E. Wilson, J. Hung
  • Materials Science, Medicine
    American journal of hospital pharmacy
  • 1 November 1993
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