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Antihypertensive activity in rats for SQ 14,225, an orally active inhibitor of angiotensin I-converting enzyme.
- R. Laffan, M. E. Goldberg, J. High, T. Schaeffer, M. Waugh, B. Rubin
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 February 1978
The results suggest that SQ 14,225 acts primarily by inhibiting the renin-angiotensin system to reduce elevated blood pressure, especially in presumably ren in-dependent models of hypertension.
EFFECT OF REPEATED INHALATION OF VAPORS OF INDUSTRIAL SOLVENTS ON ANIMAL BEHAVIOR. I. EVALUATION OF NINE SOLVENT VAPORS ON POLE-CLIMB PERFORMANCE IN RATS.
- M. E. Goldberg, H. E. Johnson, U. C. Pozzani, H. F. Smyth
- PsychologyAmerican Industrial Hygiene Association journal
- 1 July 1964
Abstract Repeated inhalation of vapors of nine industrial solvents has been investigated by study of rats selected on the basis of successful training to climb to a safety area of a chamber when…
SQ 14,225 (D-3-mercapto-2-methylpropanoyl-l-proline), a novel orally active inhibitor of angiotensin I-converting enzyme.
Effects of chronic treatment with captopril (SQ 14,225), an orally active inhibitor of angiotensin I-converting enzyme, in spontaneously hypertensive rats.
Results indicate that chronic inhibition of ACE with captopril induces normalization of blood pressure in SHR, a normal-renin model of hypertension.
Chronic antihypertensive effects of captopril (SQ 14,225), an orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats.
Inhibition of angiotensin converting enzyme by SQ 14,225 in conscious rabbits.
Novel non-benzodiazepine anxiolytics
Effects of Δ9-Tetrahydrocannabinol (THC) and chlordiazepoxide (CDP) on state-dependent learning: evidence for asymmetrical dissociation
- M. E. Goldberg, M. Hefner, R. Robichaud, B. Dubinsky
- Biology, PsychologyPsychopharmacologia
- 21 May 1973
Results suggest that an asymmetrical dissociation exists between THC and CDP or between either agent and saline, and both agents elicited evidence for state-dependent learning.
Effects of Δ9-Tetrahydrocannabinol (THC) on Several Rodent Learning Paradigms
Δ9-THC was studied for its effects on the learning behavior of rats and mice in several experimental models of learning. Doses were selected by observation of the gross behavioral effects o