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Degeneration and the chemical composition of the human lumbar intervertebral disc
Fifteen lumbar spines were collected postmortem. The intervertebral discs were assigned morphological grades and were analyzed for water, collagen, and proteoglycan. In order of increasingExpand
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The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal
To determine the safety and efficacy of viscosupplementation with hylan G-F 20, a cross-linked hyaluronan preparation, used either alone or in combination with continuous non-steroidalExpand
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In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis.
The biosynthesis of proteoglycans in the menisci and articular cartilages of the knee (stifle) of mature beagles was studied in the early stages of experimental osteoarthritis. The rate ofExpand
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A Risk-Benefit Assessment of Injections of Hyaluronan and its Derivatives in the Treatment of Osteoarthritis of the Knee
AbstractHyaluronan is critical for the homeostasis of the joint as an organ, in part, because it provides the rheological properties (viscosity and elasticity) of the synovial fluid. These propertiesExpand
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Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis.
OBJECTIVE To quantify the gene expression of aggrecan core protein and type II collagen in an experimental animal model of osteoarthritis (OA). METHODS Total RNA was extracted from the articularExpand
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A new sulphate-reducing vibrio.
SUMMARY: An obligately anaerobic sulphate-reducing vibrio (NCIB 8382) isolated from soil from Singapore differs from known species of sulphate-reducing bacteria. The organism is relatively large,Expand
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  • Open Access
Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model
Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms.Expand
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The glycosaminoglycans of canine menisci.
The semilunar menisci of the knee have an important mechanical function and are commonly involved in joint degeneration. However, previously published analyses of the compositions of normal andExpand
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Magnetic resonance imaging of the ligaments and menisci of the knee.
Although the technique is still developing and the data are preliminary, MRI will likely be the best noninvasive method for evaluating the ligaments and menisci of the knee. It can provide valuableExpand
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