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Ionic conductances contributing to spike repolarization and after‐potentials in rat medial vestibular nucleus neurones.
1. Intracellular recordings were made from 123 tonically active medial vestibular nucleus (MVN) neurones in a horizontal slice preparation of the dorsal brainstem of the rat. On the basis of theirExpand
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Intrinsic membrane properties of vertebrate vestibular neurons: Function, development and plasticity
Central vestibular neurons play an important role in the processing of body motion-related multisensory signals and their transformation into motor commands for gaze and posture control. Over recentExpand
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Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurones after unilateral labyrinthectomy
1 The inhibitory effects of the GABAA agonist muscimol and the GABAB agonist baclofen on tonically active medial vestibular nucleus (MVN) neurones were recorded in slices of the rat dorsal brainstemExpand
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Loss of β-III Spectrin Leads to Purkinje Cell Dysfunction Recapitulating the Behavior and Neuropathology of Spinocerebellar Ataxia Type 5 in Humans
Mutations in SPTBN2, the gene encoding β-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor coordination. How these mutationsExpand
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Role of the commissural inhibitory system in vestibular compensation in the rat
We investigated the role of the vestibular commissural inhibitory system in vestibular compensation (VC, the behavioural recovery that follows unilateral vestibular loss), using in vivo microdialysisExpand
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Activation of cat muscle spindle primary, secondary and intermediate sensory endings by suxamethonium.
  • M. Dutia
  • Chemistry, Medicine
  • The Journal of physiology
  • 1 July 1980
1. These experiments were based on the recent observation of Gladden (1976), that acetylcholine (ACh) when applied to the isolated cat muscle spindle caused contraction of the dynamic and the staticExpand
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Synaptic Plasticity in Medial Vestibular Nucleus Neurons: Comparison with Computational Requirements of VOR Adaptation
Background Vestibulo-ocular reflex (VOR) gain adaptation, a longstanding experimental model of cerebellar learning, utilizes sites of plasticity in both cerebellar cortex and brainstem. However, theExpand
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Lesion‐induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation
1 We have recently shown that neurones in the rostral region of the medial vestibular nucleus (MVN) develop a sustained increase in their intrinsic excitability within 4 h of a lesion of theExpand
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The contribution of the intrinsic excitability of vestibular nucleus neurons to recovery from vestibular damage
Damage to the peripheral vestibular system results in a syndrome of ocular motor and postural abnormalities that partially and gradually abate over time in a process known as ‘vestibularExpand
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Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats
Vestibular compensation (the behavioural recovery that follows unilateral vestibular de‐afferentation), is facilitated by histamine, and is associated with increased central histamine release andExpand
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