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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
Mucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are CD161(hi)IL-18Rα(+) and eitherExpand
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Antimicrobial activity of mucosal-associated invariant T cells
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) α-chain and restriction by theExpand
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MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented byExpand
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Mucosal-associated invariant T cells: unconventional development and function.
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major histocompatibilityExpand
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Long Peptide Vaccination Can Lead to Lethality through CD4+ T Cell-Mediated Cytokine Storm
The optimization of anticancer therapeutic vaccines can lead to better efficacy but also to stronger adverse effects. In a mouse model of antitumor vaccination using a long peptide (LP), whichExpand
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A Novel Mouse Model for Stable Engraftment of a Human Immune System and Human Hepatocytes
Hepatic infections by hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium parasites leading to acute or chronic diseases constitute a global health challenge. The species tropism of theseExpand
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αIIbβ3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure–function
Glanzmann thrombasthenia (GT) is an autosomal recessive inherited bleeding disorder characterized by an impaired platelet aggregation due to defects in integrin αIIbβ3 (ITGA2B, ITGB3), a fibrinogenExpand
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A human immune system mouse model with robust lymph node development
Lymph nodes (LNs) facilitate the cellular interactions that orchestrate immune responses. Human immune system (HIS) mice are powerful tools for interrogation of human immunity but lack secondaryExpand
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Corrigendum: Antimicrobial activity of mucosal-associated invariant T cells
Nat. Immunol. 11, 701–708 (2010); published online 27 June 2010; corrected after print 13 August 2010 In the version of this article initially published, the author Shouxiong Huang (Department ofExpand
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Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver
Background & Aims Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus and how it affects disease progression are unclear. Methods We performedExpand
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