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Relish, a central factor in the control of humoral but not cellular immunity in Drosophila.
Using deletion mutants, it is shown that Relish is specifically required for the induction of the humoral immune response, including both antibacterial and antifungal peptides, and plays a key role in this response. Expand
Behavior in Light-Dark Cycles of Drosophila Mutants That Are Arrhythmic, Blind, or Both
The data, in contrast to some previous conclusions, strongly suggest that period0 (per0 ) adults are, in LD conditions, merely being "forced" into exhibiting periodic behavior. Expand
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions. Expand
The disconnected Visual System Mutations in Drosophila melanogaster Drastically Disrupt Circadian Rhythms
The dispensability of this insect's external photoreceptors for entrainment of its circadian pacemaker is discussed, and possible disco-induced abnormalities in the connections of extraocular photoreceptor to their targets in the central nervous system and/or abnormalities inThe targets themselves—which presum ably include elements of the fly's circadian clock. Expand
Isolation and Characterization of Hemolymph Clotting Factors in Drosophila melanogaster by a Pullout Method
It is shown that clotting occurs in the absence of phenoloxidase and that the Drosophila clot binds bacteria, and it is confirmed that hemolectin mutant larvae show clotting defects. Expand
Coagulation in arthropods: defence, wound closure and healing.
The well-characterized clotting cascade in horseshoe crabs is strongly activated by bacterial elicitors, in contrast to vertebrate clotting where induction relies more on endogenous signals. Expand
Proteomic Analysis of the Drosophila Larval Hemolymph Clot*
A proteomic comparison of larval hemolymph before and after clotting is presented to learn more about this process and allows the isolation of novel candidate clotting factors, leading to a more complete picture of clotting. Expand
Insect hemolymph clotting
  • M. Dushay
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 6 May 2009
While the clot’s molecular structure is not yet fully understood, progress is being made, and the loss of clotting factors has been shown to cause subtle immune defects. Expand
Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteins.
Drosophila attacin is most closely related to sarcotoxin II of Sarcophaga peregrina, but it lacks the extra domains that are unique to this protein, and the overall domain structure of the Att A gene product is identical to that of the attacins from Hyalophora cecropia. Expand
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
This work shows that prophenoloxidase release requires Jun N-terminal kinase, small Rho GTPases and Eiger, the Drosophila homolog of tumor necrosis factor, and that this process can be inhibited in vitro and in vivo using the viral apoptotic inhibitor p35. Expand