Evidence of SARS-CoV-2-Specific Memory B Cells Six Months After Vaccination With the BNT162b2 mRNA Vaccine
- A. Ciabattini, G. Pastore, D. Medaglini
- Biology, MedicineFrontiers in Immunology
- 28 September 2021
It is demonstrated that mRNA BNT162b2 vaccine elicits strong B cell immunity with spike-specific memory B cells that still persist 6 months after vaccination, playing a crucial role for a rapid response to SARS-CoV-2 virus encounter.
L‐type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one‐day storage
- P. Mugnai, M. Durante, F. Fusi
- BiologyActa Physiologica
- 1 June 2014
To develop a cheap and simple method of storing for 24‐h vascular tissue and single myocytes while preserving therein the biophysical and pharmacological characteristics of L‐type Ca2+ channels and…
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development
- G. Carullo, M. Durante, F. Fusi
- ChemistryJournal of Functional Foods
- 1 June 2019
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism.
- F. Fusi, F. Manetti, M. Durante, G. Sgaragli, S. Saponara
- Biology, MedicineVascular pharmacology
- 2016
Functional, electrophysiological and molecular docking analysis of the modulation of Cav1.2 channels in rat vascular myocytes by murrayafoline A
- S. Saponara, M. Durante, F. Fusi
- BiologyBritish Journal of Pharmacology
- 1 January 2016
The carbazole alkaloid murrayafoline A (MuA) enhances contractility and the Ca2+ currents carried by the Cav1.2 channels of rat cardiomyocytes and this study was designed to analyse the effects of MuA on vascular Cav1-2 channels.
Vasorelaxing activity of two coumarins from Murraya paniculata leaves.
The coumarins kimcuongin and murracarpin may represent a novel class of vasodilators of natural source in the search for novel chemical scaffolds leading to potential antihypertensive agents.
Vascular L-type Ca²⁺ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii.
Glypetelotine is a novel vasorelaxing agent which antagonizes L-type Ca(2+) channels and inhibits phenylephrine-induced contraction with IC50 values of 20 and 50 μM.
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents
- F. Fusi, M. Durante, S. Saponara
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 28 June 2016
Though an unambiguous divergence between MDR reverting and vascular activity is of overwhelming importance, these findings consistently contribute to the design and synthesis of novel and potent chemosensitizers.
Quercetin mitochondriotropic derivatives antagonize nitrate tolerance and endothelial dysfunction of isolated rat aorta rings.
- M. Durante, G. Sgaragli, L. Biasutto, A. Mattarei, F. Fusi
- Biology, ChemistryPlanta Medica
- 11 March 2013
Two mitochondriotropic, 4-O-triphenylphosphoniumbutyl derivatives of quercetin were compared to quercets for protection against glyceryl trinitrate-induced tolerance and endothelial dysfunction of isolated rat aorta rings and Q-3BTPI, however, turned out to cause endotocyte dysfunction per se.
In vitro vasoactivity of zerumbone from Zingiber zerumbet.
- F. Fusi, M. Durante, N. Cuong
- Biology, MedicinePlanta Medica
- 25 February 2015
Zerumbone showed an overall weak in vitro vasodilating activity, partly attributable to the blocking of the L-type Ca(2+) channel, which does not seem to represent, however, a serious threat to its widespread use.
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