Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
- M. V. Van Sickle, M. Duncan, K. Sharkey
- Biology, MedicineScience
- 14 October 2005
These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.
Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review
- J. McPartland, M. Duncan, V. Di Marzo, R. Pertwee
- Biology, ChemistryBritish Journal of Pharmacology
- 1 February 2015
The evidence indicates that CBD and THCV are not rimonabant‐like in their action and thus appear very unlikely to produce unwanted CNS effects, illustrating how in vitro mechanistic studies do not always predict in vivo pharmacology and underlie the necessity of testing compounds in vivo before drawing any conclusion on their functional activity at a given target.
Cannabidivarin is anticonvulsant in mouse and rat
- A. Hill, M. Mercier, Benjamin J. Whalley
- BiologyBritish Journal of Pharmacology
- 1 September 2012
For the first time, the anticonvulsant profile of the phytocannabinoid cannabidivarin (CBDV) is investigated in vitro and in in vivo seizure models.
Cannabidiolic acid prevents vomiting in Suncus murinus and nausea‐induced behaviour in rats by enhancing 5‐HT1A receptor activation
- D. Bolognini, E M Rock, R. Pertwee
- BiologyBritish Journal of Pharmacology
- 1 March 2013
To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5‐HT1A receptor activation in animal models.
Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
- K. Wright, M. Duncan, K. A. Sharkey
- Medicine, BiologyBritish Journal of Pharmacology
- 1 January 2008
This review of the current knowledge of CB2 receptors in the gastrointestinal tract highlights its role in regulating abnormal motility, modulating intestinal inflammation and limiting visceral sensitivity and pain.
Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor‐independent mechanism
This work investigates the anticonvulsant profiles of cannabis‐derived botanical drug substances (BDSs) rich in Cannabidivarin and containing cannabidiol (CBD) in acute in vivo seizure models and the binding of CBDV BDSs and their components at cannabinoid CB1 receptors.
Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin
- M. Fry, Pauline M. Smith, A. Ferguson
- BiologyJournal of Neuroscience
- 20 September 2006
It is shown that rat AP expresses AdipoR1 and AdipOR2 adiponectin receptor mRNA, and microinjection of adiponECTin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectionin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.
Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats.
- M. Duncan, A. Mouihate, K. Sharkey
- Biology, MedicineAmerican Journal of Physiology - Gastrointestinal…
- 1 July 2008
It is concluded that activation of CB2 receptors in the enteric nervous system of the gastrointestinal tract dampens endotoxin-induced enhanced intestinal contractility.
Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
- M. Duncan, M. A. Galic, Q. Pittman
- Biology, MedicineAmerican Journal of Physiology. Regulatory…
- 1 August 2013
Data indicate that CB1 receptors play a critical role in LPS-induced febrile responses through inhibiting TLR4-mediated cytokine production.
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non‐CB1/CB2 Gi/o linked receptor
- M. Duncan, P. Millns, D. Smart, J. Wright, D. Kendall, V. Ralevic
- Biology, ChemistryBritish Journal of Pharmacology
- 1 June 2004
The data suggest that noladin ether is acting at a prejunctional site and no interaction with TRPV1 is involved, and in mesenteric beds from pertussis toxin (PTX)‐pretreated rats, the inhibitory actions of noladdin ether on sensory neurotransmission were abolished, indicating the involvement of Gi/o protein‐coupled receptors.
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