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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
It is shown that Hh signalling promotes transcription of Cyclin E and Cyclin D, two inhibitors of Rb, and principal regulators of the cell cycle during development in Drosophila. Expand
Genetic separation of the neural and cuticular patterning functions of gooseberry.
One of the novel gsb alleles is used in order to understand the genetic interactions between gsb, wingless, and patched during the patterning of the ventral neuroectoderm, and it is found that Gsb antagonizes the Wg signal that confers neuroblast (NB) 4-2 fate. Expand
Analysis of molecular marker expression reveals neuronal homology in distantly related arthropods.
Examination of expression of Even-skipped and Engrailed, two transcription factors that serve as insect embryonic CNS markers, across a number of arthropod species concludes that despite their distant phylogenetic relationships and divergent mechanisms of neurogenesis, insects, malacostracans, branchiopods and collembolans share many common CNS components. Expand
Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin.
The mechanism by which the developmental signaling molecule Wingless generates G(1) arrest in the presumptive Drosophila wing margin is examined in detail and it is indicated that components of the Rbf/E2f pathway are targets of dMyc in Dosophila. Expand
Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G1 Cyclin-Retinoblastoma Axis
It is demonstrated that Shh/Gli2 signaling stimulates VSMC proliferation via regulation of the G1 cyclin-retinoblastoma axis and suggested that antagonists that target the Shh pathway may be therapeutically beneficial in the prevention of intimal hyperplasia. Expand
Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes
Insight is provided into the evolution of developmental genes and processes in dipterans and other arthropods, serve as a resource for those pursuing analysis of mosquito development, and will promote the design and refinement of functional analysis experiments. Expand
High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti
The results of this investigation indicate that FAIRE-seq is a powerful tool for identification of regulatory DNA in the genomes of non-model organisms, including human disease vector mosquitoes. Expand
Netrin and DCC: axon guidance regulators at the intersection of nervous system development and cancer.
The advantages of using Drosophila to study the function of Net-DCC and other axon guidance molecules in these cellular processes, as well as the potential for cancer therapeutics targeting Net- DCC are highlighted. Expand
Chitosan/interfering RNA nanoparticle mediated gene silencing in disease vector mosquito larvae.
A procedure for preparation of chitosan/interfering RNA nanoparticles that are combined with food and ingested by larvae and has been used for the successful knockdown of a number of different genes in A. gambiae and A. aegypti larvae. Expand
Culturing and egg collection of Aedes aegypti.
Blood-feeding mosquitoes, including the dengue and yellow fever vector Aedes aegypti, transmit many of the world's deadliest diseases. Such diseases have resurged in developing countries and poseExpand