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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
- J. Nangalia, C. Massie, +49 authors A. Green
- Biology, Medicine
- The New England journal of medicine
- 18 December 2013
Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients. Expand
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma.
Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection, and it is shown that the frank plasmablast lymphoma that develops in patients with this plasmsablastic variant of M CD is also positive for HHv-8 and lambda light chain. Expand
Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types
MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both… Expand
EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT
This consensus report of the EGILS (European Gastro-Intestinal Lymphoma Study) group includes recommendations on the management of gastric extranodal marginal zone B-cell lymphoma of MALT. They are… Expand
Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10.
CD10 is a phenotypic marker that specifically identifies the tumor cells in 90% of AITL, including the early cases, and provides an objective criterion for accurate and early diagnosis of A ITL. Expand
Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.
KSHV infects monotypic but polyclonal naive B cells and is associated with a range of lymphoproliferative disorders frompolyclonal isolated plasmablasts and microlymphomas to monoclonal microlyymphoma and frank plasmblastic lymphomas in MCD patients. Expand
High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease.
Within a prospective cohort study on 60 HIV-infected patients with MCD, 14 patients developed KSHV/HHV8-associated non-Hodgkin lymphoma (NHL), which fell into 2 groups, suggesting different pathogenesis. Expand
K15 Protein of Kaposi’s Sarcoma-Associated Herpesvirus Is Latently Expressed and Binds to HAX-1, a Protein with Antiapoptotic Function
- Tyson V. Sharp, Hsei-Wei Wang, +5 authors C. Boshoff
- Medicine, Biology
- Journal of Virology
- 15 January 2002
It is shown here that HAX-1 can form homodimers in vivo and is a potent inhibitor of apoptosis and therefore represents a new apoptosis regulatory protein. Expand
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
This study analyzed somatic alterations in mtDNA from 1675 tumors and identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand. Expand
KSHV- and EBV-associated germinotropic lymphoproliferative disorder.
Molecular analysis of whole tissue sections or microdissected KSHV-positive aggregates demonstrated a polyclonal or oligoclonal pattern of immunoglobulin (Ig) gene rearrangement, suggesting that these plasmablasts originated from germinal center B cells. Expand