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Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles
Abstract Engineered nanoparticles (NPs) are widely used in different technologies but their unique properties might also cause adverse health effects. In reviewing recent in vitro and in vivoExpand
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Comet assay in human biomonitoring studies: Reliability, validation, and applications
The comet assay (single‐cell gel electrophoresis), which measures DNA strand breaks at the level of single cells, is very easily applied to human lymphocytes, and therefore lends itself to humanExpand
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The comet assay: what can it really tell us?
A range of applications of the alkaline comet assay is covered, from investigations of the physicochemical behaviour of DNA, through studies of cellular responses to DNA damage, to biomonitoring ofExpand
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Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation.
NanoImpactNet is a European Commission Framework Programme 7 (FP7) funded project that provides a forum for the discussion of current opinions on nanomaterials in relation to human and environmentalExpand
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  • Open Access
Oxidative damage to DNA: do we have a reliable biomarker?
Oxidized bases in DNA can be measured directly by high-performance liquid chromatography (HPLC). 7,8-Dihydro-8-oxo-guanine (8-OHgua), as the most abundant oxidation product, is often regarded as anExpand
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Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
This review paper reports the consensus of a technical workshop hosted by the European network, NanoImpactNet (NIN). The workshop aimed to review the collective experience of working at the benchExpand
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  • Open Access
The importance of life cycle concepts for the development of safe nanoproducts.
Whilst the global players in industry are rapidly moving forward to take advantage of the new opportunities and prospects offered by nanotechnologies, it is imperative that such developments takeExpand
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  • Open Access
Time‐dependent biodistribution and excretion of silver nanoparticles in male Wistar rats
Silver nanoparticles (AgNPs) are the most commonly used nanoparticles owing to their antimicrobial properties. The motivation of the present study was (1) to analyze the effect of silver particleExpand
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Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay.
There is a need for a reliable, robust and sensitive assay for DNA repair, suitable for use with human lymphocyte samples in molecular epidemiological investigations. The comet assay (single cellExpand
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  • Open Access
DNA damage in diabetes: correlation with a clinical marker.
Levels of DNA damage in groups of 10 patients with insulin-dependent diabetes mellitus and 10 matched controls were compared using the comet assay; DNA strand breaks, oxidized pyrimidinesExpand
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