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Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that can activate the c-Jun N-terminal kinase and the p38 signaling pathways. It plays a critical role…
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
- H. Yamazaki, E. Gillam, M. Dong, W. W. Johnson, F. Guengerich, T. Shimada
- Biology, ChemistryArchives of biochemistry and biophysics
- 15 June 1997
There are differences in optimal conditions for reconstitution of substrate oxidations by various forms of human P450 enzymes, and in some P450-catalyzed reactions protein-protein interactions between P450 and b5 and other P450 proteins are very important in some oxidations catalyzed by CYP2C10, 2E1, and 3A4.
Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population.
The results showed that subjects who were homozygous and heterozygous for either one or both of the FMO3/Lys158 and F MO3/Gly308 mutant alleles had significantly lower in-vivo FMO activities than those with homozygotes wild-type alleles.
Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells.
Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p, p'-DDE in rodent 10-day Hershberger assay.
Tight-binding inhibition by α-naphthoflavone of human cytochrome P450 1A2
Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations.
It is shown that the requirement for S9 can be obviated by the engineered expression of enzymes of bioactivation within the bacterial cell, and an Ames tester strain is constructed, expressing both aromatic amine N-acetyltransferase and human cytochrome P4501A2, which detects aromaticAmine mutagenicity in the absence of S9.
Effects of 2,4-D and DCP on the DHT-induced androgenic action in human prostate cancer cells.
- Hyun-jung Kim, Young In Park, M. Dong
- Biology, ChemistryToxicological sciences : an official journal of…
- 1 November 2005
Results that 2,4-D and DCP enhanced DHT-induced AR transcriptional activity might be attributable, at least in part, to the promotion of AR nuclear translocation.
Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome…