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Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications.
As the end organ for the treatment of local diseases or as the route of administration for systemic therapies, the lung is a very attractive target for drug delivery. It provides direct access to… Expand
Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications.
Research in the area of pulmonary drug delivery has gathered momentum in the last several years, with increased interest in using the lung as a means of delivering drugs systemically. Advances in… Expand
Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology.
BACKGROUND The proliferation of inhaler devices has resulted in a confusing number of choices for clinicians who are selecting a delivery device for aerosol therapy. There are advantages and… Expand
Regional distribution of inspired gas in the lung.
- J. Milic-Emili, J. A. Henderson, M. Dolovich, D. Trop, K. Kaneko
- Journal of applied physiology
- 1 May 1966
MILK-EMILI, J., J. A. M. HENDERSON, M. B. DOLOVICH, D. TROP, AND K. KANEKO. Regional distribution of inspired gas in the lung. J. Appl. Physiol. 2 I (3) : 749-759. 1g66.-The expansion of different… Expand
Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia.
- D. Southam, M. Dolovich, P. O'Byrne, M. Inman
- American journal of physiology. Lung cellular and…
- 1 April 2002
Intranasal instillation techniques are used to deliver various substances to the upper and lower respiratory tract (URT and LRT) in mice. Here, we quantify the relative distribution achieved with… Expand
Regional distribution of ventilation and perfusion as a function of body position.
Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia
The best means for optimal delivery of drugs into lungs of infants with bronchopulmonary dysplasia (BPD) is uncertain. We aimed to measure radio‐aerosol deposition of salbutamol by jet nebulizer and… Expand
Aerosol drug delivery: developments in device design and clinical use
Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system… Expand
Pressurized aerosol versus jet aerosol delivery to mechanically ventilated patients. Comparison of dose to the lungs.
- H. Fuller, M. Dolovich, G. Posmituck, W. W. Pack, M. Newhouse
- Medicine, Chemistry
- The American review of respiratory disease
- 1 February 1990
The purpose of this study was to compare deposition of aerosol to the lung from a metered-dose inhaler (MDI) and aerosol holding chamber and from a jet nebulizer in ventilator-dependent patients.… Expand
Significant variability in response to inhaled corticosteroids for persistent asthma.
- S. Szefler, R. Martin, +18 authors C. Sorkness
- The Journal of allergy and clinical immunology
- 1 March 2002
BACKGROUND A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy. OBJECTIVE The purpose of this investigation was to compare the relative beneficial and… Expand