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Fumiquinazolines A–G, novel metabolites of a fungus separated from a Pseudolabrus marine fish
Seven new fumiquinazolines (FQs) A–G have been isolated from a strain of Aspergillus fumigatus originally separated from the marine fish Pseudolabrus japonicus and exhibited moderate cytotoxicity against cultured P388 cells.
Dehatrine, an antimalarial bisbenzylisoquinoline alkaloid from the Indonesian medicinal plant Beilschmiedia madang, isolated as a mixture of two rotational isomers.
Through bioassay-guided separations of the chemical constituents of the Indonesian medicinal plant Beilschmiedia madang BL. a bisbenzylisoquinoline alkaloid was obtained as the major antimalarial…
Absolute stereostructure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei
Interaction of indole derivatives with biologically important aromatic compounds. Part 22. Importance of simultaneous co-operation of hydrogen-bond pairing and stacking interactions for recognition…
As a model to investigate the mode of recognition of the base guanine by peptides and proteins, the crystal structure of the 7-methylguanosine-5′-phosphate–tryptophanylglutamic acid complex was…
Absolute stereostructures of cell-adhesion inhibitors, macrosphelides C, E–G and I, produced by a Periconia species separated from an Aplysia sea hare
- Takeshi Yamada, M. Iritani, M. Doi, K. Minoura, Tadayoshi Ito, A. Numata
- Chemistry, Biology
- 15 November 2001
Macrosphelides E–H inhibited the adhesion of human-leukaemia HL-60 cells to HUVEC and the absolute configuration of macrosphelide C, previously undetermined, has been established by X-ray analysis and application of the modified Mosher method.
Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors.
The X-ray analysis of the complex crystal shows that the inhibitor is located at the R-domain side, not in the center of the binding site created by theR- and L-domains of papain, which explains well the biological behavior that the inhibitors exhibits against papain.
Crystal Structures of [Met5] and [(4-Bromo)Phe4, Met5]: Formation of a Dimeric Antiparallel β-Structure
: The crystal structure of [(4-bromo)Phe4,Met5]enkephalin (Tyr-Gly-Gly-(4-bromo)-Phe-Met) shows two independent molecular conformations. The molecules are arranged in parallel in a head-to-tail…
Anthcolorins A–F, novel cytotoxic metabolites from a sea urchin-derived Aspergillus versicolor
Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source.
The Halichondria sponge-derived fungus, Gymnacella dankaliensis, was cultured in two different media conditions and two extremely unusual steroids, dankasterones A and B, exhibited significant growth inhibition against the murine P388 cancer cell line.
Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities.
- Takeshi Yamada, M. Iritani, A. Numata
- Chemistry, BiologyOrganic & biomolecular chemistry
- 28 November 2007
Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai and showed significant in vivo tumour inhibitory activity and inhibited the protein kinase EGFR and topoisomerase II.