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Fumiquinazolines A–G, novel metabolites of a fungus separated from a Pseudolabrus marine fish
TLDR
Seven new fumiquinazolines (FQs) A–G have been isolated from a strain of Aspergillus fumigatus originally separated from the marine fish Pseudolabrus japonicus and exhibited moderate cytotoxicity against cultured P388 cells.
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Dehatrine, an antimalarial bisbenzylisoquinoline alkaloid from the Indonesian medicinal plant Beilschmiedia madang, isolated as a mixture of two rotational isomers.
Through bioassay-guided separations of the chemical constituents of the Indonesian medicinal plant Beilschmiedia madang BL. a bisbenzylisoquinoline alkaloid was obtained as the major antimalarial…
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Absolute stereostructure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei
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Interaction of indole derivatives with biologically important aromatic compounds. Part 22. Importance of simultaneous co-operation of hydrogen-bond pairing and stacking interactions for recognition…
As a model to investigate the mode of recognition of the base guanine by peptides and proteins, the crystal structure of the 7-methylguanosine-5′-phosphate–tryptophanylglutamic acid complex was…
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Absolute stereostructures of cell-adhesion inhibitors, macrosphelides C, E–G and I, produced by a Periconia species separated from an Aplysia sea hare
TLDR
Macrosphelides E–H inhibited the adhesion of human-leukaemia HL-60 cells to HUVEC and the absolute configuration of macrosphelide C, previously undetermined, has been established by X-ray analysis and application of the modified Mosher method.
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Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors.
TLDR
The X-ray analysis of the complex crystal shows that the inhibitor is located at the R-domain side, not in the center of the binding site created by theR- and L-domains of papain, which explains well the biological behavior that the inhibitors exhibits against papain.
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Crystal Structures of [Met5] and [(4-Bromo)Phe4, Met5]: Formation of a Dimeric Antiparallel β-Structure
: The crystal structure of [(4-bromo)Phe4,Met5]enkephalin (Tyr-Gly-Gly-(4-bromo)-Phe-Met) shows two independent molecular conformations. The molecules are arranged in parallel in a head-to-tail…
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Anthcolorins A–F, novel cytotoxic metabolites from a sea urchin-derived Aspergillus versicolor
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Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source.
TLDR
The Halichondria sponge-derived fungus, Gymnacella dankaliensis, was cultured in two different media conditions and two extremely unusual steroids, dankasterones A and B, exhibited significant growth inhibition against the murine P388 cancer cell line.
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Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities.
TLDR
Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai and showed significant in vivo tumour inhibitory activity and inhibited the protein kinase EGFR and topoisomerase II.
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