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A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.
Processes of intestinal absorption, metabolism, and secretion must be considered simultaneously in viewing oral drug bioavailability. Existing models often fail to predict route-dependent intestinalExpand
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  • 4
  • Open Access
Pancreatic uptake of [2-(14)C]alloxan.
The uptake of [2-(14)C]alloxan by the pancreatic gland was investigated in control and streptozotocin-induced diabetic (STZ) rats, using both in vitro and in vivo techniques. Whether after 10 to 60Expand
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  • 1
Benzodiazepine sedation in critically ill patients.
  • M. Doherty
  • Medicine
  • AACN clinical issues in critical care nursing
  • 1 November 1991
Agitation is a common phenomenon in critically ill patients. This multidimensional challenge can prolong illness, interfere with treatment, and harm the patient. The nurse must assess the cause ofExpand
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Pancreatic fate of D‐[3H] mannoheptulose
D‐Mannoheptulose was recently postulated to be transported into cells by GLUT2. The validity of such an hypothesis was assessed by comparing the uptake of tritiated D‐mannoheptulose by pancreaticExpand
  • 9
Glycogen accumulation in rat pancreatic islets
Under conditions of sustained hyperglycemia, glycogen accumulates in pancreatic islets, but not so in acinar pancreatic cells. Advantage conceivably could be taken from such a situation in theExpand
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ARTHROPATHY, LEUCOPENIA AND RECURRENT INFECTION ASSOCIATED WITH A TcR γ δPOPULATION
: This report documents the presence of clonal gamma delta T-cell receptor (TcR) population in the blood of a patient who presented with an arthropathy of undetermined cause, leucopenia andExpand
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P-28 The art of dying well
  • M. Doherty
  • Medicine
  • BMJ Supportive & Palliative Care
  • 1 November 2017
The Catholic Church in England and Wales has brought the medieval manuscript Ars Moriendi – The Art of Dying – into the digital age, with a website -www.artofdyingwell.org – aimed at helpingExpand
Oxidation of D-[U-(14)C] glucose and [1,12-(14)C] dodecanedioic acid by pancreatic islets from Goto-Kakizaki rats.
In pancreatic islets from hereditarily diabetic GK rats, [1,12 -(14)C] dodecanedioic acid (5.0 mM) was oxidized at a rate representing about 5 % of that of D-[U - (14)C] glucose (8.3 mM). Dioic acidExpand