Genetic loci influencing kidney function and chronic kidney disease
- J. Chambers, Weihua Zhang, J. Kooner
- Biology, MedicineNature Genetics
- 1 May 2010
Using genome-wide association, common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine associated with chronic kidney disease are identified.
The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.
- M. Phanish, N. Wahab, P. Colville-Nash, B. Hendry, M. Dockrell
- Biology, MedicineBiochemical Journal
- 15 January 2006
Different roles for Smad2 and Smad3 are demonstrated in TGFbeta1-induced CTGF expression and markers of EMT in human PTECs, which can be of therapeutic value in designing targeted anti-fibrotic therapies for tubulo-interstitial fibrosis.
The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells.
- Ramaswamy Diwakar, A. Pearson, P. Colville-Nash, N. Brunskill, M. Dockrell
- Biology, MedicineAJP - Renal Physiology
- 1 May 2007
The results indicate that albumin-induced TGF-beta(1) secretion by PTECs does not require albumin endocytosis and therefore the mechanism for the induction of some profibrotic responses by albumin may differ from those required for some of the inflammatory responses.
Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis
- M. Phanish, S. Winn, M. Dockrell
- Biology, MedicineNephron Experimental Nephrology
- 2 December 2009
The biology of CCN2 is discussed with a focus on the regulation ofCCN2 gene, cellular mechanisms of profibrotic CCN1 effects and the current in vivo and in vitro evidence for the role of CCn2 in the development of renal fibrosis.
Development of an outpatient finger-prick glomerular filtration rate procedure suitable for epidemiological studies.
- I. Niculescu-Duvaz, L. D'Mello, J. Kwan
- MedicineKidney International
- 1 April 2006
Capillary sampling is simple, effective, and significantly reduces the time and costs of performing plasma clearance GFR measurements, which will make the GFR measurement more accessible for clinical practice and large-scale epidemiological studies may become feasible.
L-type calcium current of isolated rat cardiac myocytes in experimental uraemia.
- P. Donohoe, A. Mcmahon, A. James
- Biology, MedicineNephrology, Dialysis and Transplantation
- 1 June 2000
Renal failure is associated with rapid inactivation of cardiac ventricular myocyte L-type Ca(2+) currents, which may reduce Ca( 2+) influx and contribute to shortening of the action potential duration.
Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis.
- Mangalakumar Veerasamy, Tri Q. Nguyen, R. Motazed, A. Pearson, R. Goldschmeding, M. Dockrell
- Biology, MedicineAJP - Renal Physiology
- 1 November 2009
E-cadherin loss, the key feature of epithelial mesenchymal transition, will not necessarily be followed by total phenotype change; rather, cells may undergo some loss of phenotypic marker in a ligand-dependent manner and participate in reparative processes.
Physiological role of nitric oxide in regulation of renal function in humans.
- W. Haynes, M. F. Hand, D. Webb
- Biology, MedicineAmerican Journal of Physiology
- 1 March 1997
The physiological role of endogenous nitric oxide in regulation of renal function in humans is unclear. Eight healthy men received an inhibitor of nitric oxide synthase, N(G)-monomethyl-L-arginine…
Assessing the validity and reliability of the MUST and MST nutrition screening tools in renal inpatients.
- C. Lawson, K. Campbell, I. Dimakopoulos, M. Dockrell
- MedicineJournal of renal nutrition
- 1 September 2012
The MUST and MST nutrition tools are not sensitive enough to identify all of the malnourished renal inpatients, despite being fairly reliable and related to other nutrition status markers.
Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture.
- C. Sharpe, M. Dockrell, M. Noor, B. Monia, B. Hendry
- Biology, MedicineJournal of the American Society of Nephrology
- 1 September 2000
It is demonstrated that Ki-Ras(4B) is the predominantly expressed Ras isoform in human renal fibroblasts in primary culture and is important for both serum- and EGF-stimulated proliferation.
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