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Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy.
Recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility are reviewed. Expand
Immunological properties of engineered nanomaterials
Research shows that nanoparticles can stimulate and/or suppress the immune responses, and that their compatibility with the immune system is largely determined by their surface chemistry, and modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery. Expand
Toll receptors, CD14, and macrophage activation and deactivation by LPS.
The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed. Expand
Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution.
The ideal nanoparticle platform is the one whose integrity is not disturbed in the complex biological environment, which provides extended circulation in the blood to maximize delivery to the target site, is not toxic to blood cellular components, and is "invisible" to the immune cells which can remove it from circulation. Expand
Induction of In Vitro Reprogramming by Toll-Like Receptor (TLR)2 and TLR4 Agonists in Murine Macrophages: Effects of TLR “Homotolerance” Versus “Heterotolerance” on NF-κB Signaling Pathway Components1
It is demonstrated that induction of homotolerance affects a broader spectrum of signaling components than in heterotolerance, with selective modulation of specific elements within the NF-κB signaling pathway. Expand
Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles.
Effect of protein binding on the nanoparticle hydrodynamic size, elements of coagulation, and the complement system have been investigated and the difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are discussed. Expand
Method for analysis of nanoparticle hemolytic properties in vitro.
Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other pathological conditions; therefore the hemolytic potential of all intravenously administered pharmaceuticalsExpand
Characterization of nanoparticles for therapeutics.
Progress is highlighted for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy. Expand
Identification and Avoidance of Potential Artifacts and Misinterpretations in Nanomaterial Ecotoxicity Measurements
This manuscript recommends thorough characterization of initial ENMs including measurement of impurities, implementation of steps to minimize changes to the ENMs during storage, inclusion of a set of experimental controls, and use of orthogonal measurement methods when available to assess ENM fate and distribution in organisms. Expand
Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice.
The results of detailed in vivo therapeutic investigations demonstrating the high tumor affinity of GA-198AuNPs in severely compromised immunodeficient mice bearing human prostate tumor xenografts are reported, making these particles ideal candidates for future human applications. Expand