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Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
During limb outgrowth, signaling by bone morphogenetic proteins (BMPs) must be moderated to maintain the signaling loop between the zone of polarizing activity (ZPA) and the apical ectodermal ridgeExpand
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A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, weExpand
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Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila
BACKGROUND Studies in Drosophila have taught us a great deal about how animals regulate the immediate innate immune response, but we still know little about how infections cause pathology. Here, weExpand
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Macrophage-Derived upd3 Cytokine Causes Impaired Glucose Homeostasis and Reduced Lifespan in Drosophila Fed a Lipid-Rich Diet
Summary Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila geneticsExpand
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Exploration of host–pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
Summary The facultative intracellular bacterial pathogen Listeria monocytogenes is capable of replicating within a broad range of host cell types and host species. We report here the establishment ofExpand
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WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity
Regulating the nuclear factor-κB (NF-κB) family of transcription factors is of critical importance to animals, with consequences of misregulation that include cancer, chronic inflammatory diseasesExpand
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Mutation and Analysis of Dan, the Founding Member of the Dan Family of Transforming Growth Factor β Antagonists
ABSTRACT The Dan family of transforming growth factor β antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or theExpand
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Drosophila melanogaster Is a Genetically Tractable Model Host for Mycobacterium marinum
ABSTRACT Mycobacterium marinum is a pathogenic mycobacterial species that is closely related to Mycobacterium tuberculosis and causes tuberculosis-like disease in fish and frogs. We infected theExpand
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Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in a Salmonella-Infected Fruit Fly
Death by infection is often as much due to the host's reaction as it is to the direct result of microbial action. Here we identify genes in both the host and microbe that are involved in theExpand
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Drosophila eiger Mutants Are Sensitive to Extracellular Pathogens
We showed previously that eiger, the Drosophila tumor necrosis factor homolog, contributes to the pathology induced by infection with Salmonella typhimurium. We were curious whether eiger is alwaysExpand
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