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Contaminant fluxes from sediment due to tubificid oligochaete bioturbation
The release of the hydrophobic organic compounds pyrene, dibenzofuran and phenanthrene from bioturbated freshwater sediments was studied in laboratory microcosms. Initial Tubificid oligochaeteExpand
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Metabolic Insight of Neutrophils in Health and Disease
Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally consideredExpand
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S-glutathionylation: relevance in diabetes and potential role as a biomarker
Abstract Glutathione is considered the main regulator of redox balance in the cellular milieu due to its capacity for detoxifying deleterious molecules. The oxidative stress induced as a result of aExpand
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Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide
Apoptosis of nigral dopaminergic neurons by various mechanisms is an emerging phenomenon involved in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Both extrinsic and intrinsicExpand
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Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide
Abstract The primary pathology in Parkinson's disease patients is significant loss of dopaminergic neurons in the substantia nigra through multiple mechanisms. We previously have demonstrated theExpand
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A study on nitric oxide, beta-adrenergic receptors and antioxidant status in the polymorphonuclear leukocytes from the patients of depression.
BACKGROUND alterations in the polymorphonuclear leukocyte (PMNs) receptors, second messenger system and in their responses have been found associated with depression. Recently role ofExpand
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Models to study atherosclerosis: a mechanistic insight.
The recent failure of candidate drugs like cholesterol ester transfer protein (CETP) and acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors calls for a revised approach for screeningExpand
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Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters
Essential oil components from turmeric (Curcuma longa L.) are documented for neuroprotective, anti-cancer, anti-thrombotic and antioxidant effects. The present study aimed to investigate theExpand
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Assessment of in-utero venlafaxine induced, ROS-mediated, apoptotic neurodegeneration in fetal neocortex and neurobehavioral sequelae in rat offspring
Venlafaxine (VEN), a serotonin and noradrenaline reuptake inhibitor is being used as a drug of choice for treating clinical depression even during pregnancy. It is an important therapeutic option inExpand
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Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis
Abstract In the present study turmerone enriched curcuma oil (C.oil) obtained from Curcuma longa L. was evaluated in lipopolysaccharide (LPS) induced inflammation in THP-1 human monocytes, J774.2Expand
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