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Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation.
The recruitment of mononuclear leukocytes and formation of intimal macrophage-rich lesions at specific sites of the arterial tree are key events in atherogenesis. Inducible endothelial cell adhesionExpand
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CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.
The transforming growth factor-beta (TGF-beta) superfamily of growth factors and cytokines has been implicated in a variety of physiological and developmental processes within the cardiovascularExpand
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MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells*
Smad proteins are essential components of the intracellular signaling pathways utilized by members of the transforming growth factor-β (TGF-β) superfamily of growth factors. Certain Smad proteinsExpand
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Inhibition of E-Selectin Gene Expression by Transforming Growth Factor β in Endothelial Cells Involves Coactivator Integration of Smad and Nuclear Factor κB–Mediated Signals
Transforming growth factor (TGF)-β1 is a pleiotropic cytokine/growth factor that is thought to play a critical role in the modulation of inflammatory events. We demonstrate that exogenous TGF-β1 canExpand
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Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
Abstract For the first time in sigma‐2 (&sgr;2) receptor field, a quantitative structure–activity relationship (QSAR) model has been built using pKi values of the whole set of known selective &sgr;2Expand
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Sigma-2 receptor ligands QSAR model dataset
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2Expand
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Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.
In the search of novel strategies for the treatment of cancer, photodynamic therapy (PDT) has emerged as an effective, safe for repeated use, and non-invasive method. This technique involves the useExpand
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The egr‐1 promoter contains information for constitutive and inducible expression in transgenic mice
Egr‐1 is an immediate early gene that couples short‐term changes in the extracellular milieu to long‐term changes in gene expression. Under in vitro conditions, the Egr‐1 gene is expressed in manyExpand
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Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
Small molecule inhibitors of adipocyte fatty acid binding protein 4 (FABP4) have attracted interest following the recent publications of beneficial pharmacological effects of these compounds. FABP4Expand
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Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors
TLDR
We built a ligand database called HemeOxDB that includes the entire set of known HO‐1 and HO‐2 inhibitors, resulting in more than 400 compounds. Expand
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