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Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation.
The recruitment of mononuclear leukocytes and formation of intimal macrophage-rich lesions at specific sites of the arterial tree are key events in atherogenesis and vascular cell adhesion molecule-1 and ICAM-1 expression was increased on the endothelial cell surface in lesion-prone areas.
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.
- J. N. Topper, M. Dichiara, M. Gimbrone
- BiologyProceedings of the National Academy of Sciences…
- 4 August 1998
It is demonstrated by both a mammalian two-hybrid and a biochemical approach that human Smad2 and Smad4, two essential Smad proteins involved in mediating TGF-beta transcriptional responses in endothelial and other cell types, can functionally interact with the transcriptional coactivator CREB binding protein (CBP).
MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells*
- J. D. Brown, M. Dichiara, K. R. Anderson, M. Gimbrone, J. N. Topper
- Biology, ChemistryThe Journal of Biological Chemistry
- 26 March 1999
A novel mechanism for activation of Smad protein-mediated signaling in endothelial cells is demonstrated and it is suggested that Smad2 may act as an integrator of diverse stimuli in these cells.
Inhibition of E-Selectin Gene Expression by Transforming Growth Factor β in Endothelial Cells Involves Coactivator Integration of Smad and Nuclear Factor κB–Mediated Signals
- M. Dichiara, J. Kíely, M. Gimbrone, Mu-En Lee, M. Perrella, J. N. Topper
- BiologyThe Journal of experimental medicine
- 5 September 2000
A novel mechanism of interaction between TGF-β1–regulated Smad proteins and NFκB proteins regulated by inflammatory stimuli in vascular endothelial cells is demonstrated and may play an important role in the immunomodulatory actions of this cytokine/growth factor in the cardiovascular system.
Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
Sigma-2 receptor ligands QSAR model dataset
The egr‐1 promoter contains information for constitutive and inducible expression in transgenic mice
- J. Tsai, Lixin Liu, B. Cooley, M. Dichiara, J. N. Topper, W. Aird
- BiologyFASEB journal : official publication of the…
- 1 October 2000
Transgenic mice with a construct containing 1200 bp of the mouse Egr‐1 promoter coupled to nuclear localized LacZ are generated and these findings suggest that the Egr-1 promoter contains information for appropriate spatial and temporal expression in vivo.
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.