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Pharmacokinetics of quinolones in renal insufficiency.
- J. P. Fillastre, A. Leroy, B. Moulin, M. Dhib, F. Borsa-Lebás, G. Humbert
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
The pharmacokinetics of the new fluoroquinolone derivatives have been extensively studied in patients with various degrees of chronic renal insufficiency during the last few years. Their kinetic… Expand
Pharmacokinetics of sparfloxacin in patients with renal impairment.
- J. P. Fillastre, G. Montay, +7 authors D. Schott
- Antimicrobial Agents and Chemotherapy
- 1 April 1994
The pharmacokinetics of sparfloxacin were studied in 14 renal failure patients (group I, 7 with creatinine clearance of > 10 to 30 ml/min; and group II, 7 with creatinine clearance of < or = 10… Expand
Disposition of Fleroxacin, a New Trifluoroquinolone, and Its Metabolites
SummaryThe pharmacokinetics of fleroxacin and its metabolites following a single oral dose of fleroxacin 400mg were examined in 6 healthy subjects and 24 patients with various degrees of renal… Expand
Relationship between renal function and disposition of oral cefixime
SummaryThe pharmacokinetics of cefixime following a single oral dose of 200 mg have been investigated in 6 normal subjects and in 22 patients with various degrees of renal insufficiency. Serum and… Expand
Fatal destructive cervical spondyloarthropathy.
Thrombotic microangiopathy (TMA) as the first manifestation of HIV infection.
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism.
Serotonin (5-HT) stimulates aldosterone secretion in man through activation of 5-HT4 receptors coupled to adenylyl cyclase via a Gs regulatory protein. In adrenocortical cells, the levels of… Expand
Penetration of lomefloxacin into human prostatic tissue.
Abstract Serum and prostatic tissue concentrations of lomefloxacin were measured in 12 elderly patients who underwent transurethral resection of the prostate after receiving a single oral dose of 400… Expand
The list of nephrotoxic drugs is long. The kidney is particularly susceptible to the nephrotoxic action of drugs, because of its functional properties, including: a) the high volume of renal blood… Expand
Pharmacokinetics and pharmacodynamics of zolpidem following repeated doses in hemodialyzed uraemic patients
- J. P. Fillastre, S. Geffroy-Josse, +5 authors G. Bianchetti
- Fundamental & clinical pharmacology
- 1 February 1993
Summary— Zolpidem, an imidazopyridine derivative, is a chemically novel, non‐benzodiazepine hypnotic agent. Many uraemic patients complain of sleep disorders and ask for hypnotic medication which is… Expand