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Influence of food on the pharmacokinetics of perindopril and the time course of angiotensin‐converting enzyme inhibition in serum
Food has been shown to reduce the bioavailability of the angiotensin‐converting enzyme inhibitor captopril, but not the bioavailability of inhibitors administered as ester prodrugs. Perindopril isExpand
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Pharmacokinetics of perindopril and its metabolites in healthy volunteers
Summary— Perindopril, an angiotensin converting enzyme (ACE) inhibitor, is converted in vivo to its active diacid metabolite, perindoprilat and to a perindoprilat glucuronide. The pharmacokineticExpand
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S14080, a peripheral analgesic acting by release of an endogenous circulating opioid‐like substance
1 The oral administration of a benzothiazolinone derivative (benzoyl‐6 dihydro‐2,3 benzothiazole), S14080, caused dose‐dependent antinociception in the rat paw pressure test, which represents a modelExpand
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Long-term effects of angiotensin-converting enzyme inhibition on the arterial wall of adult spontaneously hypertensive rats.
The effects of long-term angiotensin-converting enzyme (ACE) inhibitor treatment with perindopril 2 mg/kg/day, by gavage, for 3 months on the mechanical function and structure of large arteries wereExpand
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Protective effect of angiotensin converting enzyme inhibitors (CEI): captopril and perindopril on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion in rat.
The purpose of the present study was to evaluate the effects of two CEI: captopril and perindopril on reperfusion arrhythmias and noradrenaline 3H (NA3H) release in the isolated rat heart onExpand
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Radioimmunoassay of a new angiotensin-converting enzyme inhibitor (perindopril) in human plasma and urine: advantages of coupling anion-exchange column chromatography with radioimmunoassay.
Perindopril (P) is a prodrug whose active metabolite perindoprilat (PT) is an antihypertensive agent which acts by inhibition of angiotensin-converting enzyme (ACE). Anti-PT antiserum was produced inExpand
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Remodeling of heart and arteries by chronic converting enzyme inhibition in spontaneously hypertensive rats.
Hemodynamic and structural changes of the heart and large arterial vessels were studied in normotensive and spontaneously hypertensive rats following 12 weeks administration of converting enzymeExpand
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Gas chromatography-mass spectrometry of perindopril and its active free metabolite, an angiotensin convertase inhibitor: choice of derivatives and ionization modes.
Perindopril, a perhydroindole compound and a novel class of angiotensin convertase inhibitor, after oral administration leads to an active metabolite by de-esterification of an ethyl ester. RoutineExpand
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Vascular Effects of Perindopril: From Experimental to Clinical Investigation
Summary: Vascular remodeling is central to the pathophysiology of hypertension and atherosclerosis. The effects of antihypertensive drugs on this process are important to consider from a mechanisticExpand
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