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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund et al. discover the presence of a lymphatic vessel network in the dura mater of the mouse brain and show that these dural lymphatic vessels are important for the clearance of macromoleculesExpand
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Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
VPF/VEGF is a multifunctional cytokine that contributes to angiogenesis by both direct and indirect mechanisms. On the one hand, VPF/VEGF stimulates the ECs lining nearby microvessels to proliferate,Expand
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A promoter-level mammalian expression atlas
Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mappedExpand
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeoboxExpand
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Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
OBJECTIVE MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression. In this study we investigated the expression, regulation, and function of miR-155 and miR-146a inExpand
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Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea.
The opinions set forth in this report are those of the committee members and do not represent the Food and Drug Administration in any way. R osacea is well recognized as a chronic cuta-neous disorderExpand
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Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance ofExpand
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Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma–associated herpesvirus. It is characterized by the expression of lymphatic lineage–specific genes byExpand
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Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiencyExpand
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TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays.
Cell migration plays a major role in development, physiology, and disease, and is frequently evaluated in vitro by the monolayer wound healing assay. The assay analysis, however, is a time-consumingExpand
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