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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- Aleksanteri Aspelund, Salli Antila, K. Alitalo
- Biology, ChemistryThe Journal of experimental medicine
- 29 June 2015
The presence of a lymphatic vessel network in the dura mater of the mouse brain is discovered and it is shown that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea.
The National Rosacea Society assembled a committee to develop a standard classification system that can serve as a diagnostic instrument to investigate the manifestations and relationships of the several subtypes and potential variants of rosacea.
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
It is proposed that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.
A promoter-level mammalian expression atlas
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles.
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
The occurrence and biological significance of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice are established and VEGF-C is identified as a molecular link between tumor lymphang iogenesis and metastasis.
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
It is hypothesized that the inflammatory milieu may alter miRNA expression profiles in resident cells of the rheumatoid joints and miR-155 may be involved in modulation of the destructive properties of RASFs.
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays.
TScratch, a new, freely available image analysis technique and associated software tool that uses the fast discrete curvelet transform to automate the measurement of the area occupied by cells in the images, helps to significantly reduce the time needed for analysis and enables objective and reproducible quantification of assays.
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus
It is shown that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma–associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage–specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.