M. Detke

Publications143
h-index44
Citations9,007
Highly Influential Citations471
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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
TLDR
This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth
  • M. Detke, I. Lucki
  • Psychology, Biology
    Behavioural Brain Research
  • 15 December 1995
Duloxetine, 60 mg once daily, for major depressive disorder: a randomized double-blind placebo-controlled trial.
TLDR
Duloxetine, 60 mg/day, is a well-tolerated and effective treatment for MDD that reduces painful physical symptoms and is suggested to be a first-line treatment for patients with MDD and associated painfulPhysical symptoms.
Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial
Duloxetine vs. placebo in patients with painful diabetic neuropathy
A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.
TLDR
Duloxetine was an effective and safe treatment for many of the symptoms associated with fibromyalgia in subjects with or without major depressive disorder, particularly for women, who had significant improvement across most outcome measures.
Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression.
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
TLDR
The results indicated that low doses of desipramine and fluoxetine produced different behavioral patterns in the FST, but only after chronic administration, which strengthens the validity of the F ST as a behavioral screen for antidepressant drugs with features similar to an animal model of depression.
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
TLDR
Depletion of serotonin prevented the behavioral effects of the selective serotonin reuptake inhibitor fluoxetine in the rat FST, and depletion of serotonin had no impact on the behavior effects induced by the selective norepinephrine reptake inhibitor, desipramine.
Duloxetine in the Treatment of Depression: A Double-Blind Placebo-Controlled Comparison With Paroxetine
TLDR
Duloxetine therapy was efficacious for emotional and physical symptoms of depression, with a selective serotonin reuptake inhibitor-like profile of side effects.
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