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Bovine viral diarrhea virus quasispecies during persistent infection.
TLDR
Analysis of viral genome sequences from two calves persistently infected with bovine viral diarrhea virus revealed a quasispecies distribution and it is likely that some of the variant viruses generated within these animals will differ antigenically from the persisting virus and be recognized by the immune system. Expand
Recombinant Jembrana disease virus gag proteins identify several different antigenic domains but do not facilitate serological differentiation of JDV and nonpathogenic bovine lentiviruses.
TLDR
To identify possible type-specific epitopes, a series of recombinant protein constructs including the matrix, capsid and nucleocapsid proteins were produced from JDV gag and the expressed proteins were tested by Western blot using JDV and BIV hyperimmune sera and none of the recombinant gag proteins were able to differentiate between JDV positive sera from Jembrana disease endemic and Jembran disease-free areas. Expand
Sequence analysis of Jembrana disease virus strains reveals a genetically stable lentivirus.
TLDR
JDV appears to be remarkably stable genetically and has undergone minor genetic changes over a period of nearly 20 years in Bali despite becoming endemic in the cattle population of the island. Expand
TaqMan Real-Time Reverse Transcription-PCR and JDVp26 Antigen Capture Enzyme-Linked Immunosorbent Assay To Quantify Jembrana Disease Virus Load during the Acute Phase of In Vivo Infection
TLDR
Two techniques that enable quantification of the virus and the use of these techniques to quantify the virus load during the acute phase of the disease process are reported for the first time. Expand
Detection of Jembrana disease virus in spleen, lymph nodes, bone marrow and other tissues by in situ hybridization of paraffin-embedded sections.
TLDR
Large numbers of JDV-infected cells were demonstrated in many tissue sections from experimentally infected animals early in the disease course, which was consistent with the extremely high circulating viraemia previously reported to occur during the febrile phase. Expand
Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle.
TLDR
The duration and severity of clinical parameters were found to be variable within each group of cattle but the quantification of viral load revealed the benefits of vaccinating to reduce the risk of virus transmission as well as to ameliorate disease. Expand
Jembrana disease virus: host responses, viral dynamics and disease control.
TLDR
The dynamics of JDV replication and clearance during the acute stage of Jembrana disease, the viral tropism, molecular analysis of the viral genome and mRNA transcripts, and the current status of vaccine development and diagnostic assays are reviewed to provide a greater understanding of the factors that make JDV such an unusual lentivirus. Expand
In situ hybridization as a technique for the immunological investigation of canine intestine: jejunal expression of IFNgamma and IL10 in Irish setters and beagles.
TLDR
This study has validated the use of in situ hybridization for the detection of IFNgamma and IL10 mRNA within canine intestinal biopsies, and has shown heightened jejunal expression of both cytokines in beagles with high enteric bacterial populations. Expand
Bovine immunodeficiency virus produces a transient viraemic phase soon after infection in Bos javanicus.
TLDR
Results indicated that detection of BIV in infected Bali cattle would have a greater chance of success soon after infection and prior to the onset of a CA antibody response. Expand
The coding region for the 54-kDa protein of several pestiviruses lacks host insertions but reveals a "zinc finger-like" domain.
TLDR
The predicted amino acid sequences of this 54-kDa protein portion contain a conserved cysteine-rich stretch remarkably similar to a "zinc finger-type" binding domain found in many gene-regulatory proteins, suggesting that this protein may be involved in the binding to viral RNA. Expand
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