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Vascular effects of wine polyphenols.
TLDR
This review focuses on the vascular effects of red wine polyphenols (RWPs), with emphasis on anthocyanosides and proanthocyanidins. Expand
In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).
TLDR
These studies suggest that PFCs directly suppress cytokine secretion by immune cells, and that PFOA and PFOS have different mechanisms of action. Expand
Potent inhibition of human phosphodiesterase-5 by icariin derivatives.
TLDR
4,7-bis(2-hydroxyethyl)icaritin (5), where both sugars in 1 were replaced with hydroxyethyl residues, potently inhibited PDE5A1 with an IC50 very close to that of sildenafil (IC50 75 vs 74 nM). Expand
Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling.
TLDR
Olive oil extract prevented the stimulation of MMP-9 expression and secretion in tumor necrosis factor alpha-treated THP-1 cells, a human monocyte-like cell line, providing further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis. Expand
Metabolic Syndrome and Inflammation: A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements
TLDR
Only two parameters were observed to change after treatment with botanicals in both in vitro and in vivo studies: interleukin-6 and tumour necrosis factor-α, and these biomarkers should be carefully considered in future studies for PFS benefit assessment. Expand
Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine
TLDR
Assessment of the ability of the antidepressant agomelatine to modulate specific components of the immune response in the rat brain following an inflammatory challenge with lipopolysaccharide found it significantly reduced the LPS-induced up-regulation of the pro-inflammatory cytokines interleukin-1β and interleUKin-6 in theRat brain as well as at peripheral level. Expand
Ellagitannins from Rubus Berries for the Control of Gastric Inflammation: In Vitro and In Vivo Studies
TLDR
The results of the present study report for the first time the preventing effect of ETs in gastric inflammation and support for their use in dietary regimens against peptic ulcer. Expand
In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.
TLDR
Results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. Expand
The effect of in vitro gastrointestinal digestion on the anti-inflammatory activity of Vitis vinifera L. leaves.
TLDR
The findings suggest that PFS containing water extracts from Vitis vinifera L. leaves could be useful to inhibit/attenuate gastric inflammation inhibiting IL-8 secretion and expression through impairment of the NF-κB pathway. Expand
Fruit quality of Italian pomegranate (Punica granatum L.) autochthonous varieties
TLDR
The accessions MG1, MG2, and MG3 seem particularly suitable for direct commercialization of fruits due to the fruit traits and quality (sweet varieties), while Tordimonte A and B could be valuable for juice processing (sour varieties). Expand
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