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An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex
TLDR
The x-ray structure of the complete extracellular fragment of a glycosylated αβ TCR was determined, and its orientation bound to a class I MHC-peptide (pMHC) complex was elucidated from crystals of the TCR- pMHC complex. Expand
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
TLDR
Large conformational changes in three of the TCR CDR loops are induced upon binding, providing a mechanism of structural plasticity to accommodate a variety of different peptide antigens. Expand
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.
TLDR
Weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop. Expand
Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.
TLDR
Findings from the mass spectrometry study are consistent with a general plant-steroid carrier function for Bet v 1 and related PR-10 proteins, and indicate that the hydrophobic cavity may have a role in facilitating the transfer of apolar ligands. Expand
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy‐terminal tail
TLDR
Mutational and functional studies indicate that the C‐terminal tail gates the CRFS area and the adjacent hydrophobic pocket, dynamically regulating protein quality control. Expand
Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.
TLDR
The crystal structures of catalytically competent soybean beta-amylase, unliganded and bathed with small substrates (beta-maltose, maltal), were determined and the saccharide complexes of the active enzyme are associated with a significant local conformational change in a peptide segment of a loop that borders the active site pocket. Expand
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
TLDR
The substrate binding site is unlike that from purine nucleoside phosphorylase, phosphoribosyltransferases, or uracil DNA glycosylase and thus represents a novel architecture for general acid-base catalysis. Expand
Molecular Recognition of Lipid Antigens by T Cell Receptors
TLDR
It is demonstrated that α/β TCRs, when transferred into TCR-deficient recipient cells, confer specificity for both the foreign lipid antigen and CD1 isoform. Expand
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
TLDR
The crystal structure of the 2C TCR complex of H-2Kb with superagonist peptide SIYR at 2.8 A elucidates a structural basis for TCR discrimination of altered peptide ligands and provides a new structural perspective for understanding differential signaling resulting from T cell cross-reactivity. Expand
Mycobacterium tuberculosis Pyrazinamide Resistance Determinants: a Multicenter Study
TLDR
A large multicenter study assessing pncA sequence variations in 1,950 clinical isolates identified 280 genetic variants based on their predictive value for resistance which should lead to more rapid diagnostic tests. Expand
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