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Nicotinic Receptors in the Habenulo-Interpeduncular System Are Necessary for Nicotine Withdrawal in Mice
TLDR
A major role is demonstrated for the habenulo-interpeduncular system and the nicotinic receptor subunits expressed therein, in nicotine withdrawal symptoms, which suggest that the efforts to develop new smoking cessation therapies should concentrate on these areas and receptor types. Expand
Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor.
TLDR
The findings in the alpha3-null mice suggest that this subunit is an essential component of the nicotinic receptors mediating normal function of the autonomic nervous system. Expand
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
TLDR
It is demonstrated that the α7 subunit is not essential for normal development or for apparently normal neurological function, but the mice may prove to have subtle phenotypic abnormalities and will be valuable in defining the functional role of this gene product in vivo. Expand
Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.
TLDR
It is demonstrated that the alpha7 subunit is not essential for normal development or for apparently normal neurological function, but the mice may prove to have subtle phenotypic abnormalities and will be valuable in defining the functional role of this gene product in vivo. Expand
Multiorgan Autonomic Dysfunction in Mice Lacking the β2 and the β4 Subunits of Neuronal Nicotinic Acetylcholine Receptors
TLDR
The previous description of a similar phenotype in α3−/− mice and the current data suggest that the α3 and the β4 subunits are major components in autonomic nAChRs. Expand
The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo.
TLDR
Results suggest a direct involvement of the alpha 5 subunit in the observed phenotypes of nicotine-induced behaviors and seizures in rodents. Expand
Nicotine Decreases Food Intake Through Activation of POMC Neurons
TLDR
It is demonstrated that nicotine decreases food intake and body weight by influencing the hypothalamic melanocortin system and identifies critical molecular and synaptic mechanisms involved in nicotine-induced decreases in appetite. Expand
Decreased Signs of Nicotine Withdrawal in Mice Null for the β4 Nicotinic Acetylcholine Receptor Subunit
TLDR
A major role is demonstrated for β4-containing nicotinic acetylcholine receptors in the appearance of nicotine withdrawal symptoms and the upregulation of epibatidine binding sites attributable to chronic nicotine, an effect associated with β2-containing receptors, is probably not related to the mechanisms underlying withdrawal. Expand
The Nicotinic Acetylcholine Receptor α5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
TLDR
It is shown using whole-cell electrophysiology that the relatively rare α5 subunit of the nicotinic acetylcholine receptor powerfully enhances Nicotinic currents in layer VI pyramidal neurons in prefrontal cortical brain slices from adult mice. Expand
Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors.
TLDR
Physiological studies suggest that the alpha3 and the beta4 subunits are major components in autonomic nAChRs, which resembles the autosomal recessive megacystis-microcolon-hypoperistalsis syndrome in humans. Expand
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