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Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain
TLDR
The blockade of TGF‐β signalling in vivo using a neutralizing antibody or the selective inhibitor SB‐505124 significantly improved neurogenesis in aged and irradiated mice, prevented apoptosis and increased the proliferation of neural stem/progenitor cells, suggesting that anti‐TGF‐ β‐based therapy may be used for future interventions to prevent neurogenic collapse following radiotherapy or during aging. Expand
Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage.
TLDR
It is demonstrated that quiescent NSCs are specifically enriched in the LeX(bright)/EGFR-negative population, and the GABAAR signaling is identified as a regulator of the SVZ niche size by modulating the quiescence of N SCs. Expand
Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment
TLDR
It is shown that LeXbright cells sorted from the adult mouse subventricular zone exhibit all the characteristic features of quiescent NSCs and constitute a subpopulation of slowly dividing cells that is able to enter the cell cycle to regenerate the irradiated niche. Expand
Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells
TLDR
An early decline in adult neurogenesis with a dramatic loss of progenitor cells in 4 month-old young adult mice is demonstrated and a cogent identification of new molecular players and signalling pathways regulating adult Neurogenesis and its early modifications is constituted. Expand
The prion protein is critical for DNA repair and cell survival after genotoxic stress
TLDR
Brains from Prnp−/− mice display a reduced APE1 activity and a defect in the repair of induced DNA damage in vivo, suggesting that PrP is required to maintain genomic stability in response to genotoxic stresses. Expand
The Human Papillomavirus E6 Oncogene Represses a Cell Adhesion Pathway and Disrupts Focal Adhesion through Degradation of TAp63β upon Transformation
TLDR
A major physiological role is identified for TAp63β in anchorage independent growth that might represent a new critical pathway in human carcinogenesis. Expand
TGFβ Lengthens the G1 Phase of Stem Cells in Aged Mouse Brain
TLDR
It is demonstrated that the G1 phase is lengthened during aging specifically in activated stem cells, but not in transit‐amplifying cells, and directly impacts on neurogenesis, and it is reported that inhibition of TGFβ signaling restores cell cycle progression defects in stem cells. Expand
Application of Artificial Intelligence to the Prediction of the Antimicrobial Activity of Essential Oils
TLDR
ANNs can be reliable, fast, and cheap tools for the prediction of the antimicrobial activity of EOs thus improving their use in CAM. Expand
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model
TLDR
Combined BRAFV600E and MEK inhibitor treatment was more effective in reducing tumor growth and extending animal subject survival, as corresponding to sustained MAPK pathway inhibition. Expand
Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone
TLDR
It is demonstrated that Hedgehog (Hh) signaling actively regulates different pools of quiescent and proliferative NSCs in the adult ventricular-subventricular zone (V-SVZ), one of the main brain neurogenic niches, with important implications for understanding adult neurogenesis under normal homeostatic conditions or during injury. Expand
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