The oxidative environment and protein damage.
- M. Davies
- Biology, ChemistryBiochimica et Biophysica Acta
- 17 January 2005
Singlet oxygen-mediated damage to proteins and its consequences.
- M. Davies
- Chemistry, BiologyBiochemical and Biophysical Research…
- 6 June 2003
Mammalian heme peroxidases: from molecular mechanisms to health implications.
- M. Davies, C. Hawkins, D. Pattison, Martin D. Rees
- BiologyAntioxidants and Redox Signaling
- 30 April 2008
Recent developments in the understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate are reviewed, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis are reviewed.
Biochemistry and pathology of radical-mediated protein oxidation.
- R. Dean, S. Fu, R. Stocker, M. Davies
- Biology, ChemistryBiochemical Journal
- 15 May 1997
Proteins are also key targets in defensive cytolysis and in inflammatory self-damage, and the possibility of selective protection against protein oxidation (antioxidation) is raised.
Protein oxidation and peroxidation
- M. Davies
- Biology, ChemistryBiochemical Journal
- 29 March 2016
Proteins are major targets for radicals and two-electron oxidants in biological systems due to their abundance and high rate constants for reaction. With highly reactive radicals damage occurs at…
Absolute rate constants for the reaction of hypochlorous acid with protein side chains and peptide bonds.
- D. Pattison, M. Davies
- Chemistry, BiologyChemical Research in Toxicology
- 11 September 2001
These models are useful tools for predicting, and reconciling, experimental data obtained in HOCl-induced oxidations and allow estimations to be made as to the flux of HOCl to which proteins are exposed in vivo.
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
- G. Graham, M. Davies, R. Day, A. Mohamudally, K. Scott
- Medicine, BiologyInflammoPharmacology
- 30 May 2013
The result is that paracetamol does not suppress the severe inflammation of rheumatoid arthritis and acute gout but does inhibit the lesser inflammation resulting from extraction of teeth and is also active in a variety of inflammatory tests in experimental animals.
Hypochlorite-induced oxidation of amino acids, peptides and proteins
- C. Hawkins, D. Pattison, M. Davies
- Biology, ChemistryAmino Acids
- 29 July 2003
This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions.
Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial.
Consumption of 30 g/d of alcohol (2 drinks per day) has beneficial effects on insulin and triglyceride concentrations and insulin sensitivity in nondiabetic postmenopausal women.
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
- M. Davies
- Biology, ChemistryJournal of clinical biochemistry and nutrition
- 28 December 2010
Recent developments in the understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage are reviewed.
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