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Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro
Induced pluripotent stem cell‐derived human hepatocyte‐like cells (iHeps) could provide a powerful tool for studying the mechanisms underlying human liver development and disease, testing theExpand
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Microengineered Liver Tissues for Drug Testing
Drug-induced liver injury (DILI) is a leading cause of drug attrition. Significant and well-documented differences between animals and humans in liver pathways now necessitate the use ofExpand
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Stem cell-derived liver cells for drug testing and disease modeling.
Differences between animals and humans in liver pathways now necessitate the use of in vitro models of the human liver for several applications such as drug screening. However, isolated primary humanExpand
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Superhydrophobic Coatings with Edible Materials.
We used FDA-approved, edible materials to fabricate superhydrophobic coatings in a simple, low cost, scalable, single step process. Our coatings display high contact angles and low roll off anglesExpand
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Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development.
In non-alcoholic steatohepatitis (NASH), hepatic stellate cells (HSC) differentiate into myofibroblast-like cells that cause fibrosis, which predisposes patients to cirrhosis and hepatocellularExpand
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Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver.
Due to its central role in glucose homeostasis, the liver is an important target for drug development efforts for type 2 diabetes mellitus (T2DM). Significant differences across species in liverExpand
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Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes
Hyperglycemia in type 2 diabetes mellitus has been linked to non-alcoholic fatty liver disease, which can progress to inflammation, fibrosis/cirrhosis, and hepatocellular carcinoma. Understanding howExpand
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Elderly patient with small bowel volvulus.
To the Editor: A 90-year-old man came to our emergency department complaining of a 3day history of progressively worsening abdominal pain. He reported that prior to the occurrence of abdominal pain,Expand
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A method for the improved detection of aerosolized influenza viruses and the male-specific (F+) RNA coliphage MS2
Abstract The detection of aerosolized viruses can serve as an important surveillance and control tool in agriculture, human health, and environmental settings. Here, we adapted an anion exchangeExpand
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