• Publications
  • Influence
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
TLDR
This pragmatic trial suggests that clinically meaningful antipsychotic treatment of first-episode of schizophrenia is achievable, for at least 1 year, but it cannot conclude that second-generation drugs are more efficacious than is haloperidol, since discontinuation rates are not necessarily consistent with symptomatic improvement. Expand
Dopamine in schizophrenia: a review and reconceptualization.
TLDR
The authors hypothesize that schizophrenia is characterized by abnormally low prefrontal dopamine activity leading to excessive dopamine activity in mesolimbic dopamine neurons (causing positive symptoms) and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders. Expand
Advancing paternal age and autism.
TLDR
There was a significant monotonic association between advancing paternal age and risk of ASD and possible biological mechanisms include de novo mutations associated with advancing age or alterations in genetic imprinting. Expand
A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration.
TLDR
Cognitive deterioration is slow during the early and very late stages of Alzheimer's disease and more rapid during the middle stages, suggesting that treatment trials and attempts to identify subgroups are affected. Expand
Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial.
TLDR
Relatively low doses of antipsychotic drugs lead to significant symptom amelioration in the majority of first-episode psychosis patients and in the long term, risperidone prevents relapse in more patients and for a longer time and also induces less abnormal movements than haloperidol. Expand
Self-reported attenuated psychotic symptoms as forerunners of severe mental disorders later in life.
TLDR
Self-reported APSs signal risk for later nonaffective psychotic disorders but are not clinically useful as predictors, which can be attributed to the selective enrichment strategies that produce high-risk samples. Expand
A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder.
TLDR
A nosologic distinction between nonpsychotic bipolar disease and schizophrenia in hospitalized patients is supported, supported by the results of a premorbid intellectual, language, and behavioral functioning comparison. Expand
Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.
TLDR
The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation in schizophrenia. Expand
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
TLDR
A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination. Expand
...
1
2
3
4
5
...