Biological Insights From 108 Schizophrenia-Associated Genetic Loci
- S. Ripke, B. Neale, M. O’Donovan
- Psychology, BiologyNature
- 18 July 2014
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
- R. Kahn, W. Fleischhacker, D. Grobbee
- Psychology, MedicineThe Lancet
- 29 March 2008
Dopamine in schizophrenia: a review and reconceptualization.
- K. Davis, R. Kahn, G. Ko, M. Davidson
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 November 1991
The authors hypothesize that schizophrenia is characterized by abnormally low prefrontal dopamine activity leading to excessive dopamine activity in mesolimbic dopamine neurons (causing positive symptoms) and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders.
Advancing paternal age and autism.
- A. Reichenberg, R. Gross, E. Susser
- Medicine, PsychologyArchives of General Psychiatry
- 1 September 2006
There was a significant monotonic association between advancing paternal age and risk of ASD and possible biological mechanisms include de novo mutations associated with advancing age or alterations in genetic imprinting.
A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration.
Cognitive deterioration is slow during the early and very late stages of Alzheimer's disease and more rapid during the middle stages, suggesting that treatment trials and attempts to identify subgroups are affected.
Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial.
- N. Schooler, J. Rabinowitz, G. de Smedt
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 May 2005
Relatively low doses of antipsychotic drugs lead to significant symptom amelioration in the majority of first-episode psychosis patients and in the long term, risperidone prevents relapse in more patients and for a longer time and also induces less abnormal movements than haloperidol.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
- C. Marshall, D. Howrigan, J. Sebat
- BiologyNature Genetics
- 23 February 2017
A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder.
- A. Reichenberg, M. Weiser, M. Davidson
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 December 2002
A nosologic distinction between nonpsychotic bipolar disease and schizophrenia in hospitalized patients is supported, supported by the results of a premorbid intellectual, language, and behavioral functioning comparison.
Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.
- O. Howes, R. McCutcheon, C. Correll
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 March 2017
The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation in schizophrenia.
Self-reported attenuated psychotic symptoms as forerunners of severe mental disorders later in life.
- N. Werbeloff, M. Drukker, M. Weiser
- Psychology, MedicineArchives of General Psychiatry
- 1 May 2012
Self-reported APSs signal risk for later nonaffective psychotic disorders but are not clinically useful as predictors, which can be attributed to the selective enrichment strategies that produce high-risk samples.
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