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Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic
This review details the epidemiology of CA-MRSA strains and the clinical spectrum of infectious syndromes associated with them that ranges from a commensal state to severe, overwhelming infection and addresses the therapy of these infections and strategies for their prevention. Expand
New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance.
- I. Gould, M. David, +4 authors G. Peters
- Biology, Medicine
- International journal of antimicrobial agents
- 1 June 2013
Recent pre-clinical data support a species-specific role for Panton-Valentine leukocidin in the development of acute severe S. aureus infections and elucidated other virulence mechanisms, including novel modes of internalisation, varying post-invasion strategies (featuring both upregulation and downregulation of virulence factors) and phenotypic switching. Expand
The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).
An economic simulation model is developed to quantify the costs associated with CA-MRSA infection from the societal and third-party payer perspectives and suggests early identification and appropriate treatment of CA- MRSA infections before they progress could save considerable costs. Expand
Transmission and Microevolution of USA300 MRSA in U.S. Households: Evidence from Whole-Genome Sequencing
If households serve as long-term reservoirs of USA300, household MRSA eradication programs may result in a uniquely effective control method, and it is suggested that unique USA300 MRSA isolates are transmitted within households that contain an individual with an SSTI. Expand
Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus in the United States: A Meta-Analysis
A meta-analysis of published studies that included trend data from a single site or region and derive summary epidemic curves of CA-MRSA spread over time reveals a dramatic increase in infections over the past two decades, with CA- MRSA strains now endemic at unprecedented levels in many US regions. Expand
Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecology.
- L. Miller, S. Eells, +7 authors R. Daum
- Clinical infectious diseases : an official…
- 1 June 2012
In the study population, USA300 MRSA appeared more transmissible among household members compared with other S. aureus genetic backgrounds, and decolonization strategies may need to address extra-nasal colonization and the consequences of eradicating S.Aureus disease. Expand
Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus.
The current understanding of the biological basis of MRSA virulence is summarized and future directions for research are explored, including potential vaccines and antivirulence therapies under development that might allow clinicians to more successfully treat and prevent MRSA infections. Expand
USA300 Methicillin-Resistant Staphylococcus aureus, United States, 2000–2013
It is confirmed that USA300 in the West and Midwest and subsequent diffusion to the East Coast is confirmed. Expand
Predominance of Methicillin-Resistant Staphylococcus aureus among Pathogens Causing Skin and Soft Tissue Infections in a Large Urban Jail: Risk Factors and Recurrence Rates
- M. David, Connie Mennella, Mohamed Mansour, S. Boyle-Vavra, R. Daum
- Journal of Clinical Microbiology
- 6 August 2008
Few risk factors differentiated MRSA from MSSA S STIs, and detainee patients with MRSA SSTI patients are at high risk for recurrent SSTIs. Expand
Contrasting Pediatric and Adult Methicillin-resistant Staphylococcus aureus Isolates
- M. David, S. Crawford, S. Boyle-Vavra, M. Hostetler, D. C. Kim, R. Daum
- Emerging infectious diseases
- 1 April 2006
Children may share a reservoir of MRSA strains that have an antimicrobial drug resistance profile distinct from that of adults, according to a study published in JAMA Oncology. Expand