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Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing, wheezing and breathlessness. Although environmental factors such as allergen exposure are risk factors in theExpand
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.
Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700, a humanizedExpand
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.
We have shown previously in normal subjects that a sensory measure, the Urge-to-Cough rating, increases at concentrations of inhaled capsaicin that are lower than those necessary to elicit reflexExpand
Efficacy and safety of mometasone furoate nasal spray in nasal polyposis.
BACKGROUND Studies have suggested that topical corticosteroids are effective in the treatment of nasal polyps; however, this has yet to be confirmed in a large, robust clinical trial. OBJECTIVE ToExpand
Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis.
BACKGROUND Mometasone furoate nasal spray (MFNS) 400 microg, twice daily, as adjunctive treatment with oral antibiotic significantly improved symptoms of recurrent rhinosinusitis. OBJECTIVE ToExpand
Rhinosinusitis: Developing guidance for clinical trials
The Rhinosinusitis Initiative was developed by 5 national societies. The current guidance document is an expansion of the 2004 publication, “Rhinosinusitis: Establishing definitions for clinicalExpand
Added relief in the treatment of acute recurrent sinusitis with adjunctive mometasone furoate nasal spray. The Nasonex Sinusitis Group.
BACKGROUND Intranasal glucocorticoids are effective in the treatment of allergic rhinitis. Their effectiveness as an anti-inflammatory adjunct in the treatment of acute recurrent sinusitis has notExpand
Rhinosinusitis: Developing guidance for clinical trials.
The Rhinosinusitis Initiative was developed by 5 national societies. The current guidance document is an expansion of the 2004 publication, "Rhinosinusitis: Establishing definitions for clinicalExpand
A randomized controlled trial of mometasone furoate nasal spray for the treatment of nasal polyposis.
OBJECTIVE To evaluate the efficacy and safety of mometasone furoate nasal spray (NS) for the treatment of nasal polyposis. DESIGN Randomized, double-blind, placebo-controlled, parallel-group,Expand
Effectiveness of antihistamines in the symptomatic management of the common cold.
A multicentric trial compared the effect of chlorpheniramine maleate with a placebo on the signs and symptoms of the common cold. Two hundred seventy-one patients were domiciled for 48 hours andExpand
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