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Haemozoin in Schistosoma mansoni.
a Departamento de Bioquimica Medica, Uni6ersidade Federal do Rio de Janeiro, Cidade Uni6ersitaria, 21941-590, Rio de Janeiro, RJ, Brazil b Di6isao de Quimica, Setor de Quimica Orgânica, CENPES,Expand
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A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome
SUMMARY The hard tick Boophilus microplus ingests large volumes of cattle blood, as much as 100 times its own mass before feeding. Huge amounts of haem are produced during haemoglobin digestion,Expand
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Binding and storage of heme by vitellin from the cattle tick, Boophilus microplus.
We have previously shown (, Curr. Biol. 9, 703-706) that the cattle tick Boophilus microplus does not synthesize heme, relying solely on the recovery of the heme from the diet to make all itsExpand
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Expression and immunolocalization of a Boophilus microplus cathepsin L‐like enzyme
Efforts are being undertaken to control tick infestations that cause important economic losses. A cathepsin L‐like endopeptidase of Boophilus microplus was expressed in Escherichia coli; theExpand
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Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion.
A large amount of heme is produced upon digestion of red cell hemoglobin in the midgut of mosquitoes. The interaction between heme and the peritrophic matrix (PM) was studied in Aedes aegypti. ByExpand
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Haemozoin formation in the midgut of the blood‐sucking insect Rhodnius prolixus
Malaria parasites digest haemoglobin and detoxify the free haem by its sequestration into an insoluble dark‐brown pigment known as haemozoin (Hz). Until recently, this pigment could be found only inExpand
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Perimicrovillar membranes promote hemozoin formation into Rhodnius prolixus midgut.
Rhodnius prolixus is a hematophagous insect that ingests large quantities of blood in each blood-feeding session. This ingested blood provides important nutrients to sustain the insect's oogenesisExpand
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Antioxidant Role of Rhodnius prolixus Heme-binding Protein
Heme in aqueous solutions actively promotes free radical reactions leading to degradation of biological molecules. The blood-sucking insect Rhodnius prolixus has a heme-binding protein (RHBP) in itsExpand
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Alpha-Glucosidase Promotes Hemozoin Formation in a Blood-Sucking Bug: An Evolutionary History
Background Hematophagous insects digest large amounts of host hemoglobin and release heme inside their guts. In Rhodnius prolixus, hemoglobin-derived heme is detoxified by biomineralization, formingExpand
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