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The cytotoxic activity of ursolic acid derivatives.
Ursolic acid and 2alpha-hydroxyursolic acid isolated from apple peels were found to show growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela. StructuralExpand
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Synthesis and Antifungal Activities of Myristic Acid Analogs
Myristic acid analogs that are putative inhibitors of N‐myristoyl‐transferase were tested in vitro for activity against yeasts (Saccharomyces cerevisiae, Candida albicans, Cryptococcus neoformans)Expand
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Synthesis of chlorogenic acid derivatives with promising antifungal activity.
Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compoundsExpand
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Nonclassical biological activities of quinolone derivatives.
Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is flexible and can be easily adapted to prepare new congeners with rationally devised structures. This isExpand
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Synthesis and in vitro antifungal activity of 2-aryl-5-phenylsulfonyl-1,3,4-thiadiazole derivatives.
The synthesis and antifungal activity of a series of 2-nitroaryl-5-phenylsulfonyl-1,3,4-thiadiazoles (5a-e) are described. The in vitro antifungal activity of the compounds was determined against aExpand
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Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line.
1. A commercially-available human cytochrome P450 isozyme (CYP2D6) preparation was used in imipramine metabolism studies. This isozyme catalysed both aromatic C-oxidation and N-demethylation.Expand
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Synthesis, anti-fungal and 1,3-β-D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives.
New derivatives of caffeic acid and quinic acid were synthesized and their anti-fungal and inhibitory activities on fungal 1,3-β-glucan synthase were determined in comparison with those of theExpand
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Phenylpropanoid glycosides from Stellera chamaejasme
Abstract Two new phenylpropanoid glycosides, [4-(3- β - d -glucopyranosyloxy-1- E -propenyl)-2,6-dimethoxyphenyl]-6- O - β - d -gluco pyranosyl- β - d -glucopyranoside and [4-(3-hydroxy-1- ZExpand
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POLYCYCLIC QUINOLONES (PART 1) THIENO〔2,3-b〕BENZO〔h〕QUINOLINE DERIVATIVES : DESIGN, SYNTHESIS, PRELIMINARY IN VITRO AND IN SILICO STUDIES
Heterocyclic systems with a quinoline nucleus represent the most spectacular example of privileged molecules in medicinal chemistry, as their biological activities are surely affected by changes inExpand
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Modulatory effect of cAMP on fungal ergosterol level and inhibitory activity of azole drugs.
The functions and biosynthesis of sterols have been effective targets for fungal control in different areas, including pharmaceutical and agricultural applications. Fungi are among the organisms thatExpand
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