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Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels.
TLDR
The data provide evidence that age, diabetes and BMI are associated with higher TMAO levels independently of L-carnitine, and support the hypothesis of T MAO as a cardiovascular risk marker. Expand
[3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
TLDR
The Kd values of the recently introduced radioligand [3H]RS79948-197 were determined for the recombinant human and rat alpha2A-, alpha2B- and alpha2C- adrenoceptor subtypes as well as guinea pig alpha2b- andalpha2c-adrenoceptors expressed in COS (CV-1 Origin, SV40). Expand
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
TLDR
It is shown for the first time that TMA/TMAO production from quaternary amines could be decreased by targeting bacterial TMA-production and the production of pro-atherogenic TMAO can be suppressed by shifting the microbial degradation pattern of supplemental/dietary quaternARY amines. Expand
Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction
TLDR
Experimental evidence is provided that the long-term administration of mildronate not only decreases free carnitine concentration, but also causes a significant increase in GBB concentration, which correlates with the cardioprotection of mildRONate. Expand
Comparative pharmacological activity of optical isomers of phenibut.
TLDR
It is concluded that the pharmacological activity of racemic Phenibut relies on R-phenibut and this correlates to the binding affinity of enantiomers of phenibut to the GABAB receptor. Expand
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues
TLDR
Results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates. Expand
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.
TLDR
The results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN and support the hypothesis that GlO1 activity modulates the phenotype of DN. Expand
Melanocortins in brain inflammation: the role of melanocortin receptor subtypes.
TLDR
Recently synthesized ligands selective for individual MC receptors indicated that both MC4 and MC3 agonists are promising anti-inflammatory agents in treatment of brain inflammation. Expand
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
TLDR
Long-chain acylcarnitines are harmful FA intermediates, accumulating in ischaemic heart mitochondria and inducing inhibition of oxidative phosphorylation, and decreasing the acylCarnitine content via cardioprotective drugs may represent a novel treatment strategy. Expand
Mildronate: cardioprotective action through carnitine-lowering effect.
TLDR
Biochemical and pharmacological evidence supports the hypothesis that the mechanism of action of mildRONate is based on its regulatory effect on carnitine concentration, whereby mildronate treatment shifts the myocardial energy metabolism from fatty acid oxidation to the more favorable glucose oxidation under ischemic conditions. Expand
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