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Guidelines on nicotine dose selection for in vivo research
TLDR
A new, experimentally based compilation of species-specific dose selection for studies on the in vivo effects of nicotine, addressing issues related to genetic background, age, acute vs chronic exposure, route of administration, and behavioral responses is provided.
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Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
TLDR
It is shown that the homozygous α4−/− mice no longer express high-affinity [ 3H]nicotine and [3H]epibatidine binding sites throughout the brain, and patch-clamp recordings reveal that raphe magnus and thalamic neurons no longer respond to nicotine.
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Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse
TLDR
It is suggested that withdrawal from nicotine can be modulated by genetic factors, daily nicotine intake, duration of nicotine exposure, and withdrawal history.
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The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice.
TLDR
Data suggest that the beta2 subunit of the nAChR is critically involved in nicotine reward as measured by CPP, a major component of nicotine addiction in wild-type mice.
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Bupropion is a nicotinic antagonist.
TLDR
Bupropion was found to block nicotine's antinociception, motor effects, hypothermia, and convulsive effects with different potencies in the present investigation, suggesting that bupropion possesses some selectivity for neuronal nicotinic receptors underlying these various Nicotinic effects.
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Nicotine Dependence and Reward Differ between Adolescent and Adult Male Mice
TLDR
Using rubidium efflux assays, it was found that adolescent nicotinic receptors in different brain areas displayed significantly increased functionality compared with adult receptors, suggesting that the effectiveness of smoking cessation therapies will differ for various age groups.
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The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice
TLDR
Data suggest that the β2 subunit of the nAChR is critically involved in nicotine reward as measured by CPP, which is similar to that shown in wild-type mice.
View on Springer
Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors
TLDR
The results suggest that clinical and behavioral effects of bupropion arise from actions at nAChR as well as DA and NE transporters and that the (2S,3S)-hydroxybupropion isomer may be a better drug candidate for smoking cessation because of its higher potency at the relevant targets.
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Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs
TLDR
The results suggest that β2- containing nAChRs are involved in the affective signs of nicotine withdrawal, whereas non-β2-containing nAR subtype composition may play an important role in the involvement of specific subtypes in nicotine withdrawal.
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Role of α5 Nicotinic Acetylcholine Receptors in Pharmacological and Behavioral Effects of Nicotine in Mice
TLDR
Results show that α5(−/−) mice are less sensitive to the initial effects of nicotine in antinociception, locomotor activity, and hypothermia measures and that the α5 nAChR is involved in nicotine reward.
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