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RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility.
The proton RBE-LET relationship for cell inactivation is shifted to lower LET values compared with that for heavier ions, and the RBE for mutation induction increased continuously with LET. Expand
Inactivation of human normal and tumour cells irradiated with low energy protons.
RBE for inactivation with high-LET protons increased with the cellular radioresistance to gamma-rays, and a similar trend has been found in studies reported in the literature with He, C, N ions with LET in the range 20-125 keV/microm on human tumour cell lines. Expand
DNA DSB induction and rejoining in V79 cells irradiated with light ions: a constant field gel electrophoresis study.
The hypothesis that complex, less reparable DSB are induced in higher proportion by light ions with respect to gamma-rays and that, for the same ion, increasing LET leads to an increase in this proportion is supported. Expand
Inactivation of C3H10T1/2 cells by low energy protons and deuterons.
No difference in effectiveness for inactivation of C3H10T1/2 has been found between protons and deuterons at two LET values in the range 10-20 keV/microm and proton RBE values are significantly larger than unity at LET values as low as 11 keV /microm. Expand
Micronuclei, CREST-positive micronuclei and cell inactivation induced in Chinese hamster cells by radiation with different quality.
Good correlations between MN induction and cell inactivation were observed for both low- and high-LET radiation, indicating that the MN assay can be a useful tool to predict cell sensitivity to densely ionizing radiation with implications for tumour therapy with protons. Expand
DNA fragmentation in mammalian cells exposed to various light ions.
The results suggest that a random breakage mechanism can describe with a reasonable approximation the DNA fragmentation induced by gamma rays, while the approximation is not so good for light ions, likely due to the interplay between ion tracks and chromatin organization at the loop level. Expand
Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4β,10α-diol on memory impairment in a mouse model of Alzheimer.
Results show that ARD, HDS and PDA significantly ameliorated the Aβ1-42 peptide-induced memory impairment in the passive avoidance task and may be potential candidates for Alzheimer's disease therapy. Expand
Inactivation of human cells exposed to fractionated doses of low energy protons: relationship between cell sensitivity and recovery efficiency.
Within the framework of radiation biophysics research in the hadrontherapy field, split-dose studies have been performed on four human cell lines with different radiation sensitivity (SCC25, HF19,Expand
Reduction of the gamma-ray component from 252Cf fission neutron source--optimization for biological irradiations and comparison with MCNP code.
To enable radiobiological experiments at as high a dose rate as possible, Monte Carlo calculations for several filter materials (Al, Fe, Pb and concrete) have been made using MCNP neutron and photon transport code version 4a. Expand