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Muscle biopsy — a practical approach
- M. Dalakas
- MedicineThe Ulster Medical Journal
- 1 April 1986
In this age of modern era, the use of internet must be maximized, not only for important thing but also for daily activities, as many people suggest.
Polymyositis and dermatomyositis
Polymyositis, dermatomyositis and inclusion-body myositis.
- M. Dalakas
- MedicineThe New England journal of medicine
- 21 November 1991
The evolution over the past 10 years of rather well defined clinical, demographic, histologic, and immunopathological criteria and the identification of inclusion-body myositis as a distinct type of polymyositis now means the inflammatory myopathies now are considered to be pathogenetically similar.
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle
It is suggested that the mutations associated with the identification of distinct missense mutations in a skeletal/ventricular ELC and RLC are associated with a rare variant of cardiac hypertrophy as well as abnormal skeletal muscle.
A controlled trial of high-dose intravenous immune globulin infusions as treatment for dermatomyositis.
High-dose intravenous immune globulin is a safe and effective treatment for refractory dermatomyositis and changes in immune-mediated muscle abnormalities were determined by repeated muscle biopsies.
Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy
This multicenter, randomized, double‐blind, crossover trial compared a 6 week course of oral prednisolone tapering from 60 mg to 10 mg daily with intravenous immunoglobulin (IVIg) 2.0 g/kg given over…
Mitochondrial toxicity of antiviral drugs
A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.
Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
Correlating phenotype and genotype in the periodic paralyses
This series of 226 patients (127 kindreds) confirms some clinical features of this disorder with notable exceptions: in this series, patients without mutations had a less typical clinical presentation including an older age at onset, no changes in diet as a precipitant, and absence of vacuolar myopathy on muscle biopsy.
Sporadic inclusion body myositis—diagnosis, pathogenesis and therapeutic strategies
- M. Dalakas
- Biology, MedicineNature Clinical Practice Neurology
- 1 August 2006
Emerging data imply that continuous upregulation of cytokines and major histocompatibility complex class I on the muscle fibers causes an endoplasmic reticulum stress response, resulting in intracellular accumulation of misfolded glycoproteins and activation of the transcription factor NFκB, leading to further cytokine activation.